Results 201 to 210 of about 47,013 (254)

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

open access: yesAdvanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen   +17 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

open access: yesAdvanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo   +16 more
wiley   +1 more source

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

open access: yesAdvanced Science, EarlyView.
Glioma resection surgery is challenging because of the infiltrative growth of the tumor into nearby tissue and the different surgical requirements for gliomas with different mutation types. To improve the precision and effectiveness of glioma resection, this study developed a new imaging probe that enables the tumor boundary and mutation status to be ...
Dongdong Wu   +12 more
wiley   +1 more source

The Spanish flu

Presse Medicale, 2022
The Spanish flu occurred at the end of the First world war, in disastrous epidemiological conditions on populations exhausted by four years of war. At that time, there were no vaccines, no antibiotics, no oxygen and no resuscitation. It was even thought that the infectious agent was a bacterium.
Patrick Berche
exaly   +3 more sources

The virologist and the flu

Journal of Clinical Virology, 2015
We report a case of a virologist - who is in age-appropriate medical condition with no relevant chronic diseases - who shed influenza A H3N2 virus RNA for 70 days while infectious virus could be detected by cell culture only up to 5 days after onset of symptoms despite a 5-day course of oseltamivir.
Sabine, Wicker, Holger F, Rabenau
openaire   +2 more sources

‘Bird flu’

Nursing Management, 2006
Although H5N1 remains a flu virus that affects mostly birds, and all human cases so far have followed close contact with infected birds, there is concern, and some confusion, among the public about the difference between avian and pandemic flu.
openaire   +2 more sources

Flu on the farm

Nature, 2019
Farms help to spread influenza but they might be an early warning system for the next human pandemic. Farms help to spread influenza but they might be an early warning system for the next human pandemic.
openaire   +2 more sources

H1N1 Flu

Plastic Surgical Nursing, 2009
Centers for Disease Control and Prevention, U.S. Department of Health & Human Services.
openaire   +2 more sources

Avian flu

Nursing Management, 2005
Media reports about an infection of a different nature, avian flu, are often contradictory and sometimes confusing, which can prompt patients and clients to turn to healthcare professionals for advice about the disease.
openaire   +2 more sources

Flu pandemic

Nursing Management, 2009
A website has been launched by the London School of Hygiene and Tropical Medicine to obtain information on flu directly from the public and thereby monitor the progress of the disease this autumn.
openaire   +2 more sources

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