Results 61 to 70 of about 163,944 (309)

Vitamin D and acute respiratory infections: prevention or treatment?

open access: yesМедицинский совет, 2019
Vitamin D has a large number of biological effects due to the effect on the vitamin D receptor, which is present in most tissues in  the body. The possible role of vitamin D in infections is explained by its effect on the mechanisms of the innate and ...
N. B. Lazareva   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

FLU-PRO domain and total score by diary days 1 to 14: Influenza-Negative Patients.

open access: yes, 2018
FLU-PRO domain and total score by diary days 1 to 14: Influenza-Negative Patients.
Andrea Dugas (4993790)   +29 more
core   +1 more source

The role of probiotic agents in the prevention of seasonal incidence of ARVI

open access: yesМедицинский совет, 2013
Acute respiratory viral infection, including influenza, remains one of the most pressing health, social and economic problems of our time. The reason is the significant seasonal prevalence of the diseases in all age groups, and a high risk of serious ...
N. L. Kunelskaya   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Adequate therapy of acute respiratory infections and flu

open access: yesМедицинский совет, 2015
Acute respiratory infections (ARVI) including flu are the most widespread pathologies in the structure of children's infectious diseases [1]. The article tells about the main causative agents of ARVI in children, the clinical patterns of ARVI and flu ...
E. M. Ovsyannikova   +4 more
doaj   +1 more source

Impact of Influenza Vaccination on Mortality in the Oldest Old: A Propensity Score-Matched Cohort Study

open access: yesVaccines, 2020
Influenza remains a major cause of illness and death in geriatric populations. While the influenza vaccine has successfully reduced morbidity and mortality, its effectiveness is suspected to decrease with age.
Pauline Walzer   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Just a 'bad flu'? How death notices debunk that Covid-19 myth [PDF]

open access: yes, 2020
Analysis: Excess mortality shows that Covid-19 killed more people in one month than the most recent severe flu season did in three.
Dempsey, Rebecca   +3 more
core   +2 more sources

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