Results 91 to 100 of about 315,978 (276)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Spin-boson models for quantum decoherence of electronic excitations of biomolecules and quantum dots in a solvent

, 2005
We give a theoretical treatment of the interaction of electronic excitations (excitons) in biomolecules and quantum dots with the surrounding polar solvent.
Barthel J, Bayliss N, Birge R R, Bottcher C, Chaikin P M, Costi T A, Förster T, Gilmore J McKenzie R H, Hayashi S, Hines A P, Hsu C P, Hu X, Joel Gilmore, Kubo R, Lakowicz J R, Leggett A J, Mahan G D, Mahan G D, Makhlin Y, Mukamel S, Nemkovich N A, Niemeyer C M, Onsager L, Reichardt C, Rickayzen G, Ross H McKenzie, Sullivan K F, Tomasi J, van Holde K E, Weiss U, Yarkony D R, Yoda M   +31 more
core   +1 more source

Lightcone fluctuations in flat spacetimes with nontrivial topology [PDF]

, 1999
The quantum lightcone fluctuations in flat spacetimes with compactified spatial dimensions or with boundaries are examined. The discussion is based upon a model in which the source of the underlying metric fluctuations is taken to be quantized linear ...
B. S. DeWitt, C. J. Isham, C. J. Isham, C. W. Misner, G. Amelino-Camelia, Hongwei Yu, J. D. Bekenstein, L. H. Ford, L. H. Ford, L. H. Ford, L. H. Ford, L. H. Ford, S. Deser, W. Pauli   +13 more
core   +4 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Non-Gaussianity from Symmetry

, 2008
We point out that a light scalar field fluctuating around a symmetry-enhaced point can generate large non-Gaussianity in density fluctuations. We name such a particle as an "ungaussiton", a scalar field dominantly produced by the quantum fluctuations ...
Arroja F Koyama K, Bagger J A, Buchbinder E I Khoury J Ovrut B A, Enqvist K, Felder G N, Fuminobu Takahashi, Giudice G F, Greene B, Huang Q G, Ichikawa K Suyama T Takahashi T Yamaguchi M, Kawasaki M Nakayama K Sekiguchi T Suyama T Takahashi F, Kofman L, Komatsu E (WMAP Collaboration), Linde A, Lyth D H, Lyth D H, Lyth D H, Maldacena J M, Malik K A, Mamaev S G, Polchinski J, Seery D, Seery D, Starobinsky A A, Starobinsky A A, Suyama T Takahashi F, Teruaki Suyama, Yadav A P S Wandelt B D, Zeldovich Y B, Zeldovich Y B   +29 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

High temperature fiber optic microphone having a pressure-sensing reflective membrane under tensile stress [PDF]

, 1992
A fiber optic microphone is provided for measuring fluctuating pressures. An optical fiber probe having at least one transmitting fiber for transmitting light to a pressure-sensing membrane and at least one receiving fiber for receiving light reflected ...
Cuomo, Frank W., Hopson, Purnell, Jr., Robbins, William E., Zuckerwar, Allan J.   +3 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source