Results 41 to 50 of about 4,662 (189)

Enabling Digital Continuity in Virtual Manufacturing for Eco‐Efficiency Assessment of Lightweight Structures by Means of a Domain‐Specific Structural Mechanics Language: Requirements, Idea and Proof of Concept

open access: yesAdvanced Engineering Materials, EarlyView.
This article presents a solver‐agnostic domain‐specific language (DSL) for computational structural mechanics that strengthens interoperability in virtual product development. Using a hierarchical data model, the DSL enables seamless exchange between diverse simulation tools and numerical methods.
Martin Rädel   +3 more
wiley   +1 more source

Interaction of Liquid Steel with Mould Flux in Continuous Casting Bloom Mould - Numerical Simulations and Industrial Experiences

open access: yesArchives of Metallurgy and Materials, 2016
The device under examination is a mould of a capacity of 0.5 Mg and with inner cross-section of 280×400 mm. The virtual model of the facility under investigation was made using Gambit, DesignModeler and Meshing programs. Computer simulation of the liquid
Cwudziński A., Jowsa J., Przegrałek P.
doaj   +1 more source

Simulation of Natural Convection in a Concentric Hexagonal Annulus Using the Lattice Boltzmann Method Combined with the Smoothed Profile Method

open access: yesMathematics, 2020
This research work presents results obtained from the simulation of natural convection inside a concentric hexagonal annulus by using the lattice Boltzmann method (LBM). The fluid flow (pressure and velocity fields) inside the annulus is evaluated by LBM
Suresh Alapati
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

open access: yesAdvanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales   +11 more
wiley   +1 more source

Radiation‐Resistant Aluminum Alloy for Space Missions in the Extreme Environment of the Solar System

open access: yesAdvanced Materials, EarlyView.
A novel ultrafine‐grained aluminum crossover alloy exhibits unprecedented radiation resistance and mechanical stability under extreme irradiation doses up to 100 dpa. The exceptional resilience arises from thermodynamically stable T‐phase precipitates, enabling lightweight structural materials for next‐generation spacecraft and extraterrestrial ...
Patrick D. Willenshofer   +9 more
wiley   +1 more source

Comparação dos métodos VOF e FE/CV aplicados à solução de problemas de RTM

open access: yesVetor, 2012
A moldagem por transferência de resina (RTM) é um processo amplamente utilizado na produção de compósitos poliméricos com as mais diferentes geometrias.
Cristiano Peres Oliveira   +4 more
doaj   +4 more sources

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

open access: yesAdvanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade   +19 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

open access: yesAdvanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu   +12 more
wiley   +1 more source

Parametric investigation of boundary layer control using triangular micro vortex generators

open access: yesEPJ Web of Conferences, 2014
Improving the aerodynamic performance of an airfoil is one of the primary interests of the Aerodynamicists. Such performance improvement can be achieved using passive or active flow control devices. One of such passive devices having a compact size along
Bagheri Milad   +8 more
doaj   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

open access: yesAdvanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding   +5 more
wiley   +1 more source

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