Results 101 to 110 of about 2,957,052 (252)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Fluid-motion effects on the dynamics of thermal frontal polymerization
Thermal frontal polymerization (FP) is a process that rapidly converts liquid monomer solutions into solid polymers via self-sustaining exothermic reaction fronts. It is a promising method for polymer manufacturing because it is fast and energy-efficient.
78th APS Division of Fluid Dynamics Annual Meeting 2025 +2 more
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On micropolar fluid flow [PDF]
, 2011 Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.New fundamental solutions for micropolar fluids have been obtained in explicit form by considering Stokes and Oseen ...
Shu, Jian Jun, Shu, Jian-Jun
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fluid: Free Fluid Flux-Barriers Rotor for Synchronous Reluctance Motor Drawing
, 2018 <p># fluid</p> <p>Free Fluid Flux-Barriers Rotor for Synchronous Reluctance Motor Drawing</p> <p>## Goal</p> <p>Provide a ready-to-use fully parametric drawing of the<br> Synchronous Reluctance Rotor ...
Giacomo Bacco
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Viscoelastic local dynamics of microtubes conveying fluid
, 2018 In the present study, a nonlinear coupled scale-dependent continuum model is developed to examine the local dynamics of a pulsatile fluid-conveying microscale tube.
Ghayesh, M. +2 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2007 Since 1987, the Petroleum Division of the American Chemical Society (ACS) has sponsored at 3 year intervals an international symposium on fluid cracking catalysts (FCC) technology.
International Symposium on Advances in Fluid Cracking Catalysts(7th) +1 more
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Proteomic analysis for the study of amniotic fluid protein composition [PDF]
, 2009 Amniotic fluid (AF), routinely used for prenatal diagnosis, contains large amounts of proteins produced by the amnion epithelial cells, fetal tissues, fetal excretions and placental tissues. Although many amniotic fluid proteins have been identified and
Giorlandino, Claudio +8 more
core +1 more source