Results 91 to 100 of about 4,627,367 (300)

Metastability and nucleation in the dilute fluid phase of a simple model of globular proteins

, 1999
The dilute fluid phase of model globular proteins is studied. The model possesses a fluid-fluid transition buried within the fluid-crystal coexistence region, as do some globular proteins.
Sear, Richard P.
core  

Fluid-Fluid and Fluid-Solid transitions in the Kern-Frenkel model from Barker-Henderson thermodynamic perturbation theory

, 2012
We study the Kern-Frenkel model for patchy colloids using Barker-Henderson second-order thermodynamic perturbation theory. The model describes a fluid where hard sphere particles are decorated with one patch, so that they interact via a square-well (SW ...
Giacometti, Achille, Gögelein, Christoph, Romano, Flavio, Sciortino, Francesco   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Non-Linear Creep of Spherical Container with Fluid Under Increasing Pressure

Engineering Proceedings
This paper presents an analysis of the time-dependent response of a spherical container to internal pressure that increases over time. The wall of the container is relatively thin, in the sense that the wall thickness is negligible in comparison to the ...
Victor Rizov
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

DIETARY PRACTICES OF AEROBIC DANCERS AND BODYBUILDERS IN VHEMBE DISTRICT, LIMPOPO PROVINCE: ASSESSING THE NEED FOR NUTRITION INTERVENTION STRATEGIES

Global Journal of Public Health Medicine
Introduction: Recreational sports have gained popularity in South Africa. However, the dietary practices of participants remain unknown. The study evaluated the nutrient and timing of intake of recreational sports participants in the Vhembe District (VD),
Raymond Ramashidzha, Sefora Makuse, Sylven Masoga   +2 more
doaj   +1 more source

Nonlinear dynamic analysis of rotating pipe conveying fluid by the finite element method

Transport, 2003
The rotating pipe conveying fluid is considered. Non-linear (geometrical non-linearity) equation of the motion of the pipe is derived using the finite element method.
Marijonas Bogdevičius
doaj   +1 more source

Perfect hypermomentum fluid: variational theory and equations of motion

, 1998
The variational theory of the perfect hypermomentum fluid is developed. The new type of the generalized Frenkel condition is considered. The Lagrangian density of such fluid is stated, and the equations of motion of the fluid and the Weyssenhoff-type ...
Amorim R., Babourova O. V., de Ritis R., Demianski M., Hehl F. W., Kopczyński W., Ray J. R., Smalley L. L., Trautman A., Trautman A., Trautman A., Tunyak V. N., Vshivtsev A. S., Weyssenhoff J.   +13 more
core   +2 more sources