Results 51 to 60 of about 2,856,124 (242)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fluid Balance in the Critically Ill Child Section: “How Bad Is Fluid in Neonates?”

Frontiers in Pediatrics, 2021
Fluid overload (FO) in neonates is understudied, and its management requires nuanced care and an understanding of the complexity of neonatal fluid dynamics.
Austin Rutledge, Heidi J. Murphy, Matthew W. Harer, Jennifer G. Jetton   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Computational Fluid Dynamics Modelling of Flocculation in Water Treatment: A Review [PDF]

, 2009
The principal focus of this paper is to present a critical review of current approaches to modelling the inter-related hydrodynamic, physical and chemical processes involved in the flocculation of water using Computational Fluid Dynamics (CFD).
Jefferson, B, Jefferson, Bruce, Parsons, Simon A., Bridgeman, Jonathan, Bridgeman, J., Parsons, SA   +5 more
core   +1 more source

Predictors of bronchopulmonary dysplasia occurrence and severity in extremely preterm infants

Frontiers in Pediatrics
BackgroundBronchopulmonary dysplasia (BPD) is a common complication in extremely preterm infants (EPIs), and there is currently a lack of effective preventive strategies.
Xuejing Liu, Xuejing Liu, Xuejing Liu, Wanxian Zhang, Wanxian Zhang, Wanxian Zhang, Fangrui Ding, Fangrui Ding, Fangrui Ding   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The role of 6-hour fluid resuscitation and 24-hour fluid balance in the prognosis of patients with septic shock

Guangxi Yike Daxue xuebao
Objective To investigate the effects of early 6-hour fluid resuscitation and 24-hour cumulative fluid balance on 28-day mortality in patients with septic shock, and to evaluate their potential interaction.
Qingmei Wu, Junyu Lu
doaj   +1 more source

Association between Cumulative Fluid Balance and Outcomes in Acute Respiratory Distress Syndrome Patients Treated with Extracorporeal Membrane Oxygenation

Journal of Chest Surgery, 2021
Background: Extracorporeal membrane oxygenation (ECMO) has become increasingly accepted as a life-saving procedure for patients with severe acute respiratory distress syndrome (ARDS).
Jun Hee Lee, Jong Yun Won, Ji Eon Kim, Hee Jung Kim, Jae Seung Jung, Ho Sung Son   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source