Results 101 to 110 of about 1,191,394 (284)

Revisiting the role of fluid imbibition in the hydrocarbon recovery processes from shale reservoirs [PDF]

Spontaneous imbibition has recently received a great deal of research attention for improving hydrocarbon recovery from shale gas and oil reservoirs. It is highly desirable to know the true significance and the role of fluid imbibition in the recovery ...
Guo, Boyun, Wortman, Philip
core   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Investigation of smoothed particle hydrodynamics (SPH) method for modeling of two-phase flow through porous medium: application for drainage and imbibition processes

Scientific Reports
The drainage and imbibition processes are critical mechanisms in petroleum engineering. These processes in a porous medium are controlled by surface forces and pressure gradients. The study of these processes in the pore scale by common simulators always
Masoud Mohammadi, Masoud Shafiei, Taha Zarin, Yousef Kazemzadeh, Rafat Parsaei, Masoud Riazi   +5 more
doaj   +1 more source

Experimental and numerical study on the relationship between water imbibition and salt ion diffusion in fractured shale reservoirs

, 2017
Field observations demonstrate that shale gas wells feature a low flowback efficiency (<30%) and high salinity flowback water (approximately 200kppm) after multistage hydraulic fracturing operations.
Li J, 杨柳, Ge HK, Cao WK, Shi, X (reprint author), China Univ Petr East China, Sch Petr Engn, Qingdao 266580, Peoples R China., Zhang YJ, Gao M, Zhou T, Zhang KH, Yang, L (reprint author), China Univ Petr, State Key Lab Petr Resources & Prospecting, Beijing 102249, Peoples R China., Shi X   +10 more
core   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

ANALYSIS OF SPONTANEOUS IMBIBITION IN FRACTAL TREE-LIKE NETWORK SYSTEM [PDF]

, 2016
Spontaneous imbibition in porous media is common in nature, imbibition potential is very important for understanding the imbibition ability, or the ability to keep high imbibition rate for a long time.
Su S, Ge HK, Yang ZH, Shen, YH (reprint author), China Univ Petr, Unconvent Nat Gas Inst, Beijing 102249, Peoples R China., Li CX(李曹雄), Shen YH   +5 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Imbibition behaviors in shale nanoporous media from pore-scale perspectives [PDF]

, 2023
In shale reservoirs, spontaneous imbibition is an important mechanism of fracturing fluid loss, which has an important impact on enhanced oil recovery and water resource demand.
Cai, Jianchao, Jin, Zhehui, Li, Guanqun, Wang, Wendong, Wang, Han, Su, Yuliang   +5 more
core  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source