Results 181 to 190 of about 4,332,918 (396)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Tracking CO₂ migration and accumulation in the Subei Basin using geochronology and fluid inclusion quantitative analysis. [PDF]

Sci Rep
Hu Y, Wang R, Huang Y, Luo J, Li S, Wen Z, Guo X, Tao Z, Liu Y, Yi Y.   +9 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Fluid inclusion and sulfur isotope thermometry of the Inkaya (Simav-Kütahya) Cu-Pb-Zn-(Ag) mineralization, NW TURKEY

Open Geosciences, 2013
Özen Yeşim, Arik Fetullah
doaj   +1 more source

Late Paleocene paleoclimate recorded in fluid inclusion of halite in Subei basin, East China. [PDF]

Sci Rep
Ding T, Pan B, Zhang H, Liu C, Yang Z, Santosh M.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Toward a near real-time magma ascent monitoring by combined fluid inclusion barometry and ongoing seismicity. [PDF]

Sci Adv
Zanon V, D'Auria L, Schiavi F, Cyrzan K, Pankhurst MJ.   +4 more
europepmc   +1 more source

CH₄ Inclusions in High-pressure Metapelite: Insights into Reduced Slab Fluids and the Deep Carbon Cycle

, 2023
Guo Zengli
openalex   +1 more source

Threshold size for fluid inclusion decrepitation

, 2015
M. Campione, N. Malaspina, M. Frezzotti
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source