Results 31 to 40 of about 305,819 (266)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Multi-Stage Metallogenesis and Fluid Evolution of the Hongtoushan Cu-Zn Volcanogenic Massive Sulfide Deposit, Liaoning Province, China: Constraints from Sulfur Isotopes, Trace Elements, and Fluid Inclusions

Applied Sciences
The Hongtoushan Cu-Zn volcanogenic massive sulfide (VMS) deposit, located in the Hunbei granite–greenstone terrane of the North China Craton, has undergone a complex, multi-stage metallogenic evolution.
Xinwei You, Ende Wang, Jianfei Fu, Yekai Men   +3 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

The origin and evolution of the ore-forming fluids at the Manondo-Choma gold prospect, Kirk range, southern Malawi

Open Geosciences, 2023
This study provides an in-depth analysis of fluid inclusions (FIs) and stable isotopes from the Manondo-Choma gold prospect in southern Malawi to understand the ore-forming mechanisms, genesis, and evolution of the hydrothermal fluids responsible for ...
Chisambi Joshua, von der Heyden Bjorn
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The source of ore fluids in the Bafq district iron oxide-apatite deposits, Central Iran: a fluid inclusion approach

Journal of Economic Geology
The Bafq metallogenic district in the Kashmar-Kerman zone, or Posht-Badam block, in the Central Iran structural zone, hosts large iron oxide-apatite deposits hosted in Early Cambrian volcanic, subvolcanic, and sedimentary rocks, as well as in Precambrian
Mobina Esmaeili Zeini, Saeed Alirezaei
doaj   +1 more source

Coupling Relationship Between Densification Characteristics and Tight Oil Accumulation of the FGSR Reservoir: A Case Study of the Chang 7 Member of the Triassic Yanchang Formation in the Zhenyuan Area of the Southwest Ordos Basin, Central China

Frontiers in Earth Science, 2022
Fine-grained sedimentary rock (FGSR) reservoirs in a deep-water sedimentary environment from the Late Triassic Yanchang Formation in the Ordos Basin in central China have huge potential for tight oil production. According to the comprehensive research of
Weiling He, Weiling He, Ruyue Wang, Ruyue Wang, Qiqi Lyu, Qiqi Lyu, Jun Liu, You Wu, You Wu   +8 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source