Results 61 to 70 of about 37,365 (307)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Diverse serpentinization and associated abiotic methanogenesis within multiple types of olivine-hosted fluid inclusions in orogenic peridotite from northern Tibet

, 2021
Hydrothermal fluids percolating through peridotite are highly enriched in abiotic CH4, which can fuel chemosynthetic microbial activity and potentially early life. In contrast to the paradigm favoring coupled abiotic methanogenesis and fluid circulation,
Ding, Xing, Li, Wan-Cai, Zhang, Long, Wang, Qiang   +3 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Liquid-vapour homogenisation of fluid inclusions in stalagmites: Evaluation of a new thermometer for paleoclimate research

, 2011
We present a new approach to determine palaeotemperatures (mean annual surface temperatures) based on measurements of the liquid–vapour homogenisation temperature of fluid inclusions in stalagmites.
Marti, Dominik, Martin Frenz, Hidalgo Staub, Rita, Yves Krüger, Frenz, Martin, Fleitmann, Dominik, Krüger, Yves, Dominik Fleitmann, Dominik Marti, Rita Hidalgo Staub   +9 more
core   +1 more source

New online method for water isotope analysis of speleothem fluid inclusions using laser absorption spectroscopy (WS-CRDS) [PDF]

, 2014
A new online method to analyse water isotopes of speleothem fluid inclusions using a wavelength scanned cavity ring down spectroscopy (WS-CRDS) instrument is presented. This novel technique allows us simultaneously to measure hydrogen and oxygen isotopes
Affolter, Stéphane, S. Affolter, M. Leuenberger, Leuenberger, M., Leuenberger, Markus, Fleitmann, D., D. Fleitmann, Affolter, S.   +7 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Hydrothermal fluids evolution from various alteration – mineralization zones of Dehsalm porphyry type system, Lut block, Eastern Iran

, 2011
منطقه اکتشافي دهسلم در خراسان جنوبي و در کمربند آتشفشاني – نفوذي بلوک لوت قرار گرفته است. تودههاي نيمه عميق حدواسط تا اسيدي مربوط به اليگوسن، درون تواليهاي آتشفشاني، ماسهسنگ و سيلتستون ائوسن نفوذ کردهاند.
Karimpour, M. H., Arjmandzadeh, R., Santos, J. F., Homam, S. M., Medina, J. M., Mazaheri, S. A.   +5 more
core   +1 more source