Results 51 to 60 of about 65,734 (256)

Trends in fluid overload-related hospitalisations among patients with diabetes mellitus: The impact of chronic kidney disease

Annals, Academy of Medicine, Singapore
Introduction: Fluid overload is a known complication in patients with diabetes mellitus, particularly those with cardiovascular and/or chronic kidney disease (CKD).
Joshua Kuan Tan, Hanis Abdul Kadir, Gek Hsiang Lim, Julian Thumboo, Yong Mong Bee, Cynthia Ciwei Lim   +5 more
doaj   +1 more source

Protocol of a pilot-scale, single-arm, observational study to assess the utility and acceptability of a wearable hydration monitor in haemodialysis patients

Pilot and Feasibility Studies, 2022
Background Fluid overload has a high prevalence in haemodialysis patients and is an important risk factor for excess mortality and hospitalisations.
Vicki Sandys, Colin Edwards, Paul McAleese, Emer O’Hare, Conall O’Seaghdha   +4 more
doaj   +1 more source

Aiming for zero fluid accumulation: First, do no harm

Anaesthesiology Intensive Therapy, 2021
Critically ill patients are often presumed to be in a state of “constant dehydration” or in need of fluid, thereby justifying a continuous infusion with some form of intravenous (IV) fluid, despite their clinical data suggesting otherwise.
Orlando R. Perez Nieto, Adrian Wong, Jorge Lopez Fermin, Eder I. Zamarron Lopez, Jose A. Meade Aguilar, Ernesto Deloya Tomas, Jorge D. Carrion Moya, Gabriela Castillo Gutierrez, Maria G. Olvera Ramos, Xiomara García Montes, Manuel Alberto Guerrero Gutiérrez, Fernando George Aguilar, Jesús Salvador Sánchez Díaz, Raúl Soriano Orozco, Eduardo Ríos Argaiz, Thierry Hernandez-Gilsoul, Roberto Secchi del Rio, Silvio Antonio Ñamendys-Silva, Manu L.N.G. Malbrain   +18 more
doaj   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1

Cell Death Discovery, 2021
Endometriosis is one of the most common disorders that causes infertility in women. Iron is overloaded in endometriosis peritoneal fluid (PF), with harmful effects on early embryo development.
Shishi Li, Yier Zhou, Qiongxiao Huang, Xiaohua Fu, Ling Zhang, Fang Gao, Zhen Jin, Limei Wu, Chongyi Shu, Xirong Zhang, Weihai Xu, Jing Shu   +11 more
doaj   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Positive cumulative fluid balance in the first 72 h is associated with adverse outcomes following heat stroke

Environmental Disease, 2020
Objective: The objective of the study was to determine the association between positive cumulative fluid balance following heat stroke (HS) and its impact on patient outcomes.
Xiaoxue Yin, Gang Ye
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

“Hidden fluid” in the critically ill patient: A wake-up call

Journal of Clinical Sciences, 2019
Background and Aim: Fluid overload and unfavorable outcomes in critically ill patients have been demonstrated in many clinical settings, such as acute lung injury/acute respiratory distress syndrome, septic patients, and those with acute kidney injury ...
Babatunde Babasola Osinaike, Arinola A Sanusi, Shete Kunle Phillips   +2 more
doaj   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source