Results 91 to 100 of about 418,311 (280)

Simulating (electro)hydrodynamic effects in colloidal dispersions: smoothed profile method

open access: yes, 2008
Previously, we have proposed a direct simulation scheme for colloidal dispersions in a Newtonian solvent [Phys.Rev.E 71,036707 (2005)]. An improved formulation called the ``Smoothed Profile (SP) method'' is presented here in which simultaneous time ...
A. Chatterji   +40 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hyponatremia: a case report of SIAD

open access: yesClinical Management Issues, 2013
Hyponatremia, defined as serum sodium concentration
Letizia Canu   +2 more
doaj   +1 more source

Internal bores and gravity currents in a two-fluid system [PDF]

open access: yes, 2014
In this paper, a unified theory of internal bores and gravity currents is presented within the framework of the one-dimensional two-layer shallow-water equations. The equations represent four basic physical laws: the theory is developed on the basis of
Maruyama, Kiyoshi
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital

open access: yesBMC Endocrine Disorders, 2018
Background Hyponatraemia is the most common electrolyte disturbance amongst hospitalised patients. Both American and European guidelines recommend fluid restriction as first line treatment for SIADH, however differ on second line recommendations.
Kathryn Berkman   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Universal restrictions to the conversion of heat into work derived from the analysis of the Nernst theorem as a uniform limit

open access: yes, 2003
We revisit the relationship between the Nernst theorem and the Kelvin-Planck statement of the second law. We propose that the exchange of entropy uniformly vanishes as the temperature goes to zero. The analysis of this assumption shows that is equivalent
  +27 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

THE COMPLIANCE CHRONIC RENAL FAILURE PATIENT ON RESTRICTIONS LIQUIDS IN HEMODIALYSIS THERAPY

open access: yesJurnal Ners, 2017
Introduction: Nonadherence is a rampant problem among patients undergoing dialysis and can impact multiple aspects of patient care, including medications, and treatment regimens as well as dietary and fluid restriction.
Endang Sri P Ningsih   +2 more
doaj   +1 more source

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