Results 91 to 100 of about 1,767,668 (275)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Fluid stewardship and fluid restriction: do think of maintenance and fluid creep

Journal of Nepalese Society of Critical Care Medicine
Not ...
Srivatsa Nagachandan, Prashant Nasa, Manu L.N.G. Malbrain   +2 more
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

THE COMPLIANCE CHRONIC RENAL FAILURE PATIENT ON RESTRICTIONS LIQUIDS IN HEMODIALYSIS THERAPY

Jurnal Ners, 2017
Introduction: Nonadherence is a rampant problem among patients undergoing dialysis and can impact multiple aspects of patient care, including medications, and treatment regimens as well as dietary and fluid restriction.
Endang Sri P Ningsih, Agus Rachmadi, Hammad Hammad   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The relationship between hemodialysis patients’ fluid compliance and related factors, Makkah, Saudi Arabia

Saudi Journal of Kidney Diseases and Transplantation
Introduction: Adherence of hemodialysis (HD) patients to medical instructions is considered crucial for a longer life expectancy and better quality of life.
Ghanim Hamid Al-Khattabi
doaj   +1 more source

Hyponatremia: a case report of SIAD

Clinical Management Issues, 2013
Hyponatremia, defined as serum sodium concentration
Letizia Canu, Alessandro Peri, Gabriele Parenti   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PENGARUH PENGGUNAAN FLUID RESTRICTION APPLICATION TERHADAP KEPATUHAN PEMBATASAN CAIRAN PASIEN YANG MENJALANI HEMODIALISIS

, 2017
Fluid restriction is one of the important things in the success of hemodialysis implementation. Disobedience to the fluid restriction in hemodialysis patients reached 30-70%.
Zuniati, Zuniati, Sujianto, Untung, Anggorowati, Anggorowati   +2 more
core   +1 more source

Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital

BMC Endocrine Disorders, 2018
Background Hyponatraemia is the most common electrolyte disturbance amongst hospitalised patients. Both American and European guidelines recommend fluid restriction as first line treatment for SIADH, however differ on second line recommendations.
Kathryn Berkman, Kate Haigh, Ling Li, Jack Lockett, Goce Dimeski, Anthony Russell, Warrick J. Inder   +6 more
doaj   +1 more source