A Cellular Automaton-Based Computational Model for Fluid Shear Stress-Induced Differentiation and Migration of Osteoprogenitor Cells in a Microfluidic Chip [PDF]
BioengineeringThis study evaluates the mechanobiological responses of MC3T3-E1 cells to fluid shear stress utilizing a coupled CFD-CPM mesoscale framework. Computational fluid dynamics was utilized to calculate the distribution of fluid shear stress within the culture
Di Jiang +7 more
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Fluid shear stress enhances pancreatic cancer motility through YAP activation [PDF]
Clinical EpigeneticsBackground Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate due to late-stage diagnosis. Although SUIT2 sublines differ in metastatic and drug-resistant behavior, the mechanisms behind these differences are unclear.
Juan Deng +5 more
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Influence of fluid shear stress on human limbal epithelial cells [PDF]
Biochemistry and Biophysics ReportsBackground/aims: Limbal epithelial cells (LECs) have a crucial role in the maintenance of the corneal surface by migrating from the limbus to the cornea and replacing corneal epithelial cells.
Sophia Masterton, Mark Ahearne
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Effects of fluid shear stress duration on the mechanical properties of HeLa cells using atomic force microscopy. [PDF]
PLoS ONECellular mechanical properties play a critical role in physiological and pathological processes, with fluid shear stress being a key determinant. Despite its importance, the impact of fluid shear stress on the mechanical characteristics of HeLa cells and
Xinyao Zhao +5 more
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Exercise-altered fluid shear stress regulates vascular endothelial inflammation via Piezo1 [PDF]
Frontiers in PhysiologyExercise, as the primary physiological mechanism for modulating blood fluid shear stress (FSS), plays a crucial role in regulating vascular endothelial function by mediating mechanical signal transduction through the mechanosensor Piezo1.
Shuo Yang +3 more
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Fluid shear stress-dependent modulation of the basal endothelial glycocalyx. [PDF]
PLoS ONEThe vascular endothelial glycocalyx is a major regulator of endothelium function, serving as a vital mechanotransducer and barrier. Shear stress due to blood flow exerted on the apical endothelial cell (EC) and glycocalyx have been the primary focus of ...
Zoe Vittum, Solomon A Mensah
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Computational Fluid Dynamics in 3D-Printed Scaffolds with Different Strand-Orientation in Perfusion Bioreactors [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2020 Bone tissue engineering strategies use fluid flow dynamics inside 3D-scaffolds in perfusion, bioreactors mechanically stimulate cells in these scaffolds. Fluid flow dynamics depends on the bioreactor’s inlet flow rate and 3D-scaffold architecture.
Ali Reza Saatchi +5 more
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Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability. [PDF]
PLoS ONE, 2018 Ovarian cancer cells are exposed to physical stress in the peritoneal cavity during both tumor growth and dissemination. Ascites build-up in metastatic ovarian cancer further increases the exposure to fluid shear stress.
Alexandra R Hyler +6 more
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Single bout short duration fluid shear stress induces osteogenic differentiation of MC3T3-E1 cells via integrin β1 and BMP2 signaling cross-talk. [PDF]
PLoS ONE, 2013 Fluid shear stress plays an important role in bone osteogenic differentiation. It is traditionally believed that pulsed and continuous stress load is more favorable for fracture recovery and bone homeostasis.
Zhihui Mai +8 more
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The Response of Corneal Endothelial Cells to Shear Stress in an In Vitro Flow Model
Journal of Ophthalmology, 2021 Purpose. Corneal endothelial cells are usually exposed to shear stress caused by the aqueous humour, which is similar to the exposure of vascular endothelial cells to shear stress caused by blood flow. However, the effect of fluid shear stress on corneal
Sujuan Duan +6 more
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