Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Shock induced fluid structure interaction on a flexible wall in supersonic turbulent flow [PDF]
, 2011 A detailed knowledge of the flow structure interaction in supersonic flows is important for the design of future space transportation systems. Therefore this work was devoted to the investigation of the shock wave boundary layer interaction on an ...
Esser, Burkard +2 more
core
Numerical study of fluid-structure interaction of microvasculature [PDF]
4th Symposium on Fluid-Structure-Sound Interactions and Control, August 21-24, 2017, Tokyo, Japan202405 bcchAccepted ManuscriptRGCOthersThe Hong Kong Polytechnic UniversityPublishedGreen ...
Liu, Y +5 more
core +1 more source
Fluid-structure interaction in internal physiological flows [PDF]
, 2011 We provide a selective review of recent progress in the analysis of several physiological and physiologically inspired fluid-structure interaction problems, our aim being to explain the underlying physical mechanisms that cause the observed behaviors ...
Matthias Heil +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Vortex methods for fluid-structure interaction problems with deforming geometries and their application to swimming [PDF]
, 2010 We present a vortex particle-mesh method for fluid-structure interaction problems. The proposed methodology combines implicit interface capturing, Brinkmann penalization techniques, and the self-consistent computation of momentum transfer between the ...
Gazzola, Mattia +3 more
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Fluid-structure interaction for vascular flows: From supercomputers to laptops [PDF]
, 2017 Several models exist for the simulation of vascular flows; they span from simple circuit models to full three-dimensional ones that take into account detailed features of the blood and of the arterialwall. Eachmodel comeswith both benefits and drawbacks,
Deparis, Simone +5 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Numerical Modeling of Large-Displacement Fluid-Structure Interaction: Preliminary Study Aimed at Analysis of Heart Valve Dynamics [PDF]
, 2012 The demand for artificial heart valve replacements is increasing as a result of birth defects, ageing and disease. Collaboration between engineers, biologists and mathematicians is necessary to handle problems related to biocompatibility and fluid ...
Williston, Kyle Alexander
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Fluid-Structure Interaction Analysis of Parachute Finite Mass Inflation
International Journal of Aerospace Engineering, 2016 Parachute inflation is coupled with sophisticated fluid-structure interaction (FSI) and flight mechanic behaviors in a finite mass situation. During opening, the canopy often experiences the largest deformation and loading.
Xinglong Gao +2 more
doaj +1 more source