Results 81 to 90 of about 1,061,828 (287)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fluid-structure interaction modeling with chimera grids in NSMB*

ESAIM: Proceedings and Surveys, 2014
The paper presents the last few years of research at ICUBE, Team MECAFLU in the “Instabilité, Turbulence, Diphasique”group on the simulations of fluid-structure interactions applied to falling bodies using the NSMB solver.
Hoarau Yannick, Deloze Thibaut, Ponce Anthony, Pena Dorian, Dušek Jan   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Research on fluid-structure interaction vibration and bandgap properties of periodic composite hydraulic pipes

Applied Ocean Research
This research incorporates the Bragg scattering mechanism in phononic crystal theory into fluid-structure interaction vibration suppression of hydraulic pipes.
Fuming Zhou, Jian Liao, Lin He, Zongbin Chen, Xiaopeng Tan, Yundong Liang   +5 more
doaj   +1 more source

Relativistic theories of interacting fields and fluids

, 2001
We investigate divergence-type theories (DTT) describing the dissipative interaction between a field and a fluid. We look for theories which, under equilibrium conditions, reduce to the theory of a Klein-Gordon scalar field and a perfect fluid.
A. Albrecht, A. D. Dolgov, A. D. Dolgov, A. D. Linde, A. H. Guth, B. L. Hu, C. W. Misner, D. Boyanovsky, D. Jou, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Copeland, E. W. Kolb, Esteban Calzetta, F. Finelli, H. Kreiss, H. Kreiss, I. Liu, J. Lidsey, J. Stewart, L. F. Abbott, L. Kofman, L. Kofman, L. Landau, L. P. Chimento, L. P. Chimento, L. P. Kadanoff, M. E. Carrington, M. Turner, M. Turner, Marc Thibeault, R. Courant, R. Geroch, R. H. Brandenburger, S. A. Ramsey, S. A. Ramsey, S. Jeon, S. Jeon, S. Jeon, S. Khlebnikov, S. Khlebnikov, V. Mukhanov, W. A. Hiscock, W. A. Hiscock, W. Hiscock, W. Israel, W. Israel, W. Zimdahl, W. Zimdahl, W. Zimdahl, W. Zimdahl, Y. Hu   +53 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Three-Dimensional Fluid–Structure Interaction Case Study on Elastic Beam

Journal of Marine Science and Engineering, 2020
A three-dimensional T-shaped flexible beam deformation was investigated using model experiments and numerical simulations. In the experiment, a beam was placed in a recirculating water channel with a steady uniform flow in the inlet.
Mahdi Tabatabaei Malazi, Emir Taha Eren, Jing Luo, Shuo Mi, Galip Temir   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fluid-Structure Interaction Analysis of Parachute Finite Mass Inflation

International Journal of Aerospace Engineering, 2016
Parachute inflation is coupled with sophisticated fluid-structure interaction (FSI) and flight mechanic behaviors in a finite mass situation. During opening, the canopy often experiences the largest deformation and loading.
Xinglong Gao, Qingbin Zhang, Qiangang Tang   +2 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source