Results 91 to 100 of about 274,350 (299)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Fluid-structure interaction in periodic structure [PDF]
, 2018 Fluid-Structure Interaction (FSI) is defined as a combination of law and fluid dynamics and the relevant structural mechanics and the term FSI has given the best description of itself which is the interactions between fluid and structures.
Rong Xin Lee (12299264)
core +1 more source
Data Transfer Schemes in Rotorcraft Fluid-Structure Interaction Predictions
International Journal of Aerospace Engineering, 2018 For a CFD (computation fluid dynamics)/CSD (computational structural dynamics) coupling, appropriate data exchange strategy is required for the successful operation of the coupling computation, due to fundamental differences between CFD and CSD analyses.
Young H. You, Deokhwan Na, Sung N. Jung
doaj +1 more source
One-Dimensional Fluid–Structure Interaction Models in Pressurized Fluid-Filled Pipes: A Review
Applied Sciences, 2018 The present review paper aims at collecting and discussing the research work, numerical and experimental, carried out in the field of Fluid–Structure Interaction (FSI) in one-dimensional (1D) pressurized transient flow in the time-domain approach ...
David Ferras +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Application of SPH-FE method for fluid-structure interaction using immersed boundary method [PDF]
, 2018 Purpose: This paper aims to propose a new smoothed particle hydrodynamics (SPH)-finite element (FE) algorithm to study fluid–structure interaction (FSI) problems.
Kalateh, Farhoud, Koosheh, Ali
core +1 more source
Unified lagrangian formulation for fluid and solid mechanics, fluid-structure interaction and coupled thermal problems using the PFEM [PDF]
, 2015 The objective of this work is the derivation and implementation of a unifed Finite Element formulation for the solution of uid and solid mechanics, Fluid-Structure Interaction (FSI) and coupled thermal problems.Postprint (published ...
Oñate Ibáñez de Navarra, Eugenio +2 more
core +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source