Results 71 to 80 of about 1,405,837 (289)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

LABORATORY-AND-THEORETICAL STUDIES OF OPERATIONOF TWO-EQUALIZER DESIGN OF THE DEVICE FOR PULSED INJECTION OF LIQUID INTO THE WELL

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2016
The article considers a vibrator of two-equalizer design used for pulsed liquid injection into a well. The versatility of this vibrator is the ability to provide a free delivery of geophysical instruments to the bottom of the well to be treated without ...
M. Ya. Habibullin   +2 more
doaj   +1 more source

Normal modes of a compound drop [PDF]

open access: yes, 1982
The modes are characterized by their frequency, the attendant displacement of fluid boundaries, and the flow pressure fields within the fluids. The drops consist of three fluids; a core fluid, a fluid shell surrounding the core, and a host fluid ...
Elleman, D. D., Rhim, W. K., Saffren, M.
core   +1 more source

Darboux class of cosmological fluids with time-dependent adiabatic indices

open access: yes, 2000
A one-parameter family of time dependent adiabatic indices is introduced for any given type of cosmological fluid of constant adiabatic index by a mathematical method belonging to the class of Darboux transformations.
Dunne G.   +7 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

High-temperature ''hydrostatic'' extrusion [PDF]

open access: yes, 1970
Quasi-fluids permit hydrostatic extrusion of solid materials. The use of sodium chloride, calcium fluoride, or glasses as quasi-fluids reduces handling, corrosion, and sealing problems, these materials successfully extrude steel, molybdenum, ceramics ...
Hunt, J. G., Rice, R. W.
core   +1 more source

Rotational microrheology of Maxwell fluids using micron-sized wires

open access: yes, 2013
We demonstrate a simple method for rotational microrheology in complex fluids, using micrometric wires. The three-dimensional rotational Brownian motion of the wires suspended in Maxwell fluids is measured from their projection on the focal plane of a ...
Abou, Bérengère   +3 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Home - About - Disclaimer - Privacy