Results 41 to 50 of about 329,129 (244)
Quantitative assessment of antibody internalization with novel monoclonal antibodies against Alexa fluorophores. [PDF]
PLoS ONE, 2015 Antibodies against cell surface antigens may be internalized through their specific interactions with these proteins and in some cases may induce or perturb antigen internalization.
Sindy Liao-Chan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Biotransferencia de flúor de agua a diferentes tejidos de pejerrey (Odontesthes bonariensis)
Biología Acuática, 2014 La presencia de flúor (F), oligoelemento tóxico, tiene relevancia en la cadena trófica porque puede degradarse a diferentes niveles. Puede provenir del agua como alimento, siendo la ingestión crónica nociva para los seres humanos. El flúor se encontró en
María Laura Puntoriero +2 more
doaj
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Jurnal Riset Kesehatan, 2015 The Aims of this research was to know the differenrence of fluor content in saliva and plaque after was fissured sealent with Fuji VII. Research approach was experimental with Post test only group design. Research subject were twenty two children at 9-10
Endah Aryati Eko Ningtyas +2 more
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Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Educación Química, 2018 Es el décimo tercer elemento más abundante en la corteza terrestre. Se encuentra en ella principalmente como el mineral fluorita ----(CaF2)----, al que se le dio ese nombre, proveniente del latín fluere ----fluir----, debido a su empleo como fundente1 en
Laura Gssque Silva
doaj +1 more source