Results 51 to 60 of about 352,155 (275)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Jurnal Riset Kesehatan, 2015 The Aims of this research was to know the differenrence of fluor content in saliva and plaque after was fissured sealent with Fuji VII. Research approach was experimental with Post test only group design. Research subject were twenty two children at 9-10
Endah Aryati Eko Ningtyas +2 more
doaj +1 more source
Ascertaining the FRET activity between Alexa Fluor 488-LFA-1 and Alexa Fluor 555-D1-D2-Fc.
, 2014 Fluorescence emission spectra of individual fluorophore-protein conjugates, Alexa Fluor 488-LFA-1 (100 nM) and Alexa Fluor 555-D1-D2-Fc (100 nM), and a mixture of Alexa Fluor 488-LFA-1 (100 nM) and Alexa Fluor 555-D1-D2-Fc (100 nM) are compared.
Arthur Chiou (119655) +6 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Fluor et Carie Dentaire : Apport et Limite
, 2022 Le fluor est un élément largement présent dans la nature. Certains aliments et l'eau contiennent du fluor dans l’état naturel. L’impact de la découverte du fluor et leur Propriétés physico-chimiques sur les domaines de santé et d’industrie a été ...
REMITA, Bouchra +6 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 2019 Siendo la prevención la meta máxima a la que podemos aspirar como profesionales de salud, hemos considerado interesante brindar a los colegas, una reseña recordatoria de las acciones y aplicaciones de los compuestos fluorados.
De Borgarello, L. T.
core +1 more source
Educación Química, 2018 Es el décimo tercer elemento más abundante en la corteza terrestre. Se encuentra en ella principalmente como el mineral fluorita ----(CaF2)----, al que se le dio ese nombre, proveniente del latín fluere ----fluir----, debido a su empleo como fundente1 en
Laura Gssque Silva
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source