Results 171 to 180 of about 262,034 (273)

Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T‐cell immunotherapy to simultaneously reduce graft versus host disease, infection, and leukemia recurrence after allogeneic stem cell transplant

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 159-165, January 2023., 2023
Donor stem cell product undergoes CD34 stem cell selection. CD34 positive stem cells are used for transplantation. Pathogen‐ and leukemia‐specific T‐cells are manufactured from CD34 negative fraction and infused prophylactically 21 days after transplant.
David J. Gottlieb   +12 more
wiley   +1 more source

A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A multifunctional wound dressing (ACG gels) with antioxidant, local glycocontrol, and antibacterial properties to promote diabetic wound healing. Au‐CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress‐induced damage while exhibiting significant near‐infrared photothermal antibacterial activity.
Bangguo Zhou   +9 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

open access: yesAdvanced Science, EarlyView.
A novel strategy combining borate glass and ultrasound is proposed for the precise treatment of breast cancer. The locally delivered borate glass releases Ca2⁺ ions in situ, while ultrasound activates the highly expressed transient receptor potential vanilloid 2 channels in breast cancer cells. This synergistic effect induces specific calcium overload,
Haihong Zhu   +10 more
wiley   +1 more source

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