Results 211 to 220 of about 328,500 (372)

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

open access: yesAdvanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim   +6 more
wiley   +1 more source

Comparison of non-invasive and fluorescein tear film break-up time in a 65-year-old Norwegian population: a cross-sectional study. [PDF]

open access: yesBMJ Open
Tashbayev B   +8 more
europepmc   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

open access: yesAdvanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv   +10 more
wiley   +1 more source

Electrostatically Reinforced Double Network Granular Hydrogels

open access: yesAdvanced Science, EarlyView.
Electrostatically reinforced double network granular hydrogels (DNGHs) with cartilage‐like fracture energy are introduced. An empirical model predicts the composition‐dependent fracture energy based on dissipation zone size, contact area, and inter‐particle adhesion energy. Thanks to their granular structure and the inter‐particle attraction, the DNGHs
Tianyu Yuan   +3 more
wiley   +1 more source

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