Advanced Science, EarlyView.As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang +10 more
wiley +1 more source
Design and validation of a low-cost sugar-feeder for resource-poor insectaries. [PDF]
Gates Open ResStavrou-Dowd ZT +3 more
europepmc +1 more source
Fluorescein-Coloured Polygonal Patterns in the Normal Human Cornea and the Reflectographic ‘Furchenbild’ of Fischer [PDF]
, 1968 N.M.J. Schweitzer
openalex +1 more source
Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA
Advanced Science, EarlyView.In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa +5 more
wiley +1 more source
A Simple Method to Determine Diffusion Coefficients in Soft Hydrogels for Drug Delivery and Biomedical Applications. [PDF]
ACS OmegaAdeoye AJ, de Alba E.
europepmc +1 more source
Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event
Advanced Science, EarlyView.Lyme disease is caused by vascular dissemination of the bacteria Borrelia. In a 3D tissue‐engineered microvessel model, Borrelia extravasation across the blood–brain barrier is extremely rare, implying that neuroborreliosis is not caused via direct cytotoxicity.
Linus Wang +6 more
wiley +1 more source
Helix-induced full-color circularly polarized luminescence films with multiple information encryption and multi-stimuli responsiveness. [PDF]
Chem SciLi SY, Zong Y, Liu BH, Liu N, Wu ZQ.
europepmc +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Predictive value of dry eye disease signs and corneal in vivo confocal microscopy on serological activity in primary Sjögren disease. [PDF]
Medicine (Baltimore)Wang Y, Jiang X, Li J, Li X.
europepmc +1 more source