Results 241 to 250 of about 328,500 (372)

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

Advanced Science, EarlyView.
The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian   +10 more
wiley   +1 more source

Tertiary Syphilis-Induced Ocular Syphilis Complicated by Retinal Detachment. [PDF]

Cureus
Khan A, DiGiuseppe S, Mustafa M.
europepmc   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Deep learning-enabled transformation of anterior segment images to corneal fluorescein staining images for enhanced corneal disease screening. [PDF]

Comput Struct Biotechnol J
Gan F, Long X, Wu X, Luo L, Ji W, Fan H, Qin W, Yuan Y, Wu L, Zhang J, Deng H, Chen L, Cao J, Shao Y, Li X, Wan Q, Liu T, Liu K, You Z.   +18 more
europepmc   +1 more source

PK Changes of Ionizable Reporter Groups as an Index of Conformational Changes in Proteins. A Study of Fluorescein-Labelled Ribonuclease A [PDF]

, 1976
Jean‐Renaud Garel
openalex   +1 more source

IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

Advanced Science, EarlyView.
IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang   +6 more
wiley   +1 more source

Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility. [PDF]

Life (Basel)
Tan CQL, Wu D, Toh XY, Lim BX, Shih KC, Tong L, Lim CHL.   +6 more
europepmc   +1 more source

FLUORESCEIN FUNDUS PHOTOGRAPHIC STUDIES ON THE CENTRAL SEROUS RETINOPATHY

, 1969
H Yoshioka, Takashi Sugita
openalex   +2 more sources

An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment

Advanced Science, EarlyView.
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Pengxu Kong, Yu Gao, Huijuan Song, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Quantifying tear exchange during rigid contact lens wear using corneoscleral profilometry: A proof of concept study. [PDF]

Ophthalmic Physiol Opt
Iqbal A, Fisher D, Alonso-Caneiro D, Collins MJ, Vincent SJ.   +4 more
europepmc   +1 more source