Results 251 to 260 of about 80,277 (338)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

Advanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang, Xue Jiang, Bingrui Xiong, Jiayi Chen, Xin Liu, Siyuan Wang, Bofu Li, Mian Peng, Wei Li   +8 more
wiley   +1 more source

Construction of a versatile fusion protein for targeted therapy and immunotherapy. [PDF]

Protein Sci
Huang XS, Yang LT, Yang K, Zhou H, Abudureheman T, Zheng WW, Chen KM, Duan CW.   +7 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Quality assessment strategy development and analytical method selection of GMP grade biological drugs for gene and cell therapy. [PDF]

BBA Adv
Yang QE, Lee N, Johnson N, Hong J, Zhao JQ, Sun X, Zhang J.   +6 more
europepmc   +1 more source

The minimal membrane requirements for BAX-induced pore opening upon exposure to oxidative stress. [PDF]

Biophys J
Mystek P, Singh V, Horváth M, Honzejková K, Riegerová P, Evci H, Hof M, Obšil T, Šachl R.   +8 more
europepmc   +1 more source

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of <i>α7</i> Nicotinic Acetylcholine Receptor in the Rat Brain. [PDF]

Mar Drugs
Shan H, Wang N, Gao X, Wang Z, Yu J, Zhangsun D, Zhu X, Luo S.   +7 more
europepmc   +1 more source

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Breaking the Photostability and pH Limitation of Halo‐Fluoresceins through Chitosan Conjugation

Advances in Materials, 2023
Halo‐fluoresceins are widely used in cell and tissue staining, intracellular sensing, and photodynamic therapy, but their notorious photo‐instability and pH dependence restrict their applications, especially in long‐term visible light exposure and acidic
Y. Wang, Yunhe Lang, Qin Yang, Peng Wu
semanticscholar   +1 more source

Silinanyl Rhodamines and Silinanyl Fluoresceins for Super-Resolution Microscopy.

Journal of Physical Chemistry B, 2021
Single-molecule localization microscopy (SMLM) enables the visualization of biomolecules at unprecedented resolution and requires control of the fluorescent blinking (ON/OFF) states of fluorophores to detect single-molecule fluorescence without ...
D. Hara, Shin-Nosuke Uno, Takafumi Motoki, Yuji Kazuta, Yoshihiko Norimine, Masatoshi Suganuma, Shingo Fujiyama, Y. Shimaoka, K. Yamashita, Masaya Okada, Y. Nishikawa, H. Amino, S. Iwanaga   +12 more
semanticscholar   +1 more source