Results 101 to 110 of about 3,713,947 (387)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Calibrating evanescent-wave penetration depths for biological TIRF microscopy

, 2019
Roughly half of a cells proteins are located at or near the plasma membrane. In this restricted space the cell senses its environment, signals to its neighbors and ex-changes cargo through exo- and endocytotic mechanisms.
Becherer, Ute, Brunstein, Maia, Oheim, Martin, Salomon, Adi, Weissman, Adam   +4 more
core   +1 more source

Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi

Frontiers in Endocrinology, 2018
For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been ...
Juan José Muñoz, Javier García-Ceca, Sara Montero-Herradón, Beatriz Sánchez del Collado, David Alfaro, Agustín Zapata, Agustín Zapata   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A single atom detector integrated on an atom chip: fabrication, characterization and application

, 2010
We describe a robust and reliable fluorescence detector for single atoms that is fully integrated into an atom chip. The detector allows spectrally and spatially selective detection of atoms, reaching a single atom detection efficiency of 66%.
B Hessmo, Bücker R, D Fischer, D Heine, del Campo A, Folman R, Haubrich D, Heine D, J Schmiedmayer, Loudon R, M Wilzbach, Petrov P G Nyman R A Trupke M Hinds E A Kohnen M Succo M, Ruschewitz F, S Groth, S Loziczky, T Raub, W Rohringer, XiYuan Liu   +17 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Eco-friendly synthesis of magnetic activated carbon from used water filter cartridges for efficient methylene blue adsorption

Cleaner Water
Using activated carbon (AC) derived from used water filter cartridges (UWFC), we developed a waste-to-resource method to remove dyes from water. Mild reactivation at 400°C for 1 h produced AC-UWFC, which was subsequently transformed into magnetic ...
Dilip D. Anuse, Suryakant A. Patil, Ashwini A. Chorumale, Akanksha G. Kolekar, Prachi P. Bote, Laxman S. Walekar, Mukund G. Mali, Samadhan P. Pawar   +7 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Chloroplast and Cell Imaging at Submicron Resolution by Two-Photon Excitation [PDF]

, 2012
Novel, two-photon NIR excitation fluorescence correlation microspectroscopy tests and preliminary results were presented in this article with submicron resolution for concentrated suspensions of functional cells and chloroplast membranes.
I C. Baianu
core   +1 more source

Phenylpyridyl‐Fused Boroles: A Unique Coordination Mode and Weak B−N Coordination‐Induced Dual Fluorescence [PDF]

, 2020
He Jiang, Florian Rauch, Alexandra Friedrich, Johannes Krebs, Ivo Krummenacher, Rüdiger Bertermann, Jörn Nitsch, Holger Braunschweig, Maik Finze, Todd B. Marder   +9 more
openalex   +3 more sources