Results 251 to 260 of about 3,713,947 (387)

Millimeter scale profiles of chlorophyll fluorescence: Deciphering the microscale spatial structure of phytoplankton

, 2012
Mark Doubell, Jennifer C. Prairie, Hidekatsu Yamazaki   +2 more
openalex   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Quantitative stress and damage mapping in multiple network elastomers using a single mechanophore. [PDF]

Nat Commun
Sun P, Wang Q, Yang J, Chen Y, Wang Z, Qu S, Creton C, Xiao R.   +7 more
europepmc   +1 more source

Design and fabrication of SiO_2/TiO_2 and MgO/TiO_2 based high selective optical filters for diffuse reflectance and fluorescence signals extraction

, 2015
Sara Pimenta, Susana Cardoso, Adelaide Miranda, Pieter De Beule, Elisabete M. S. Castanheira, Graça Minas   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Comprehensive advances in CsPbBr₃ perovskite quantum dots for ultrasensitive fluorescent nanosensors in food safety monitoring. [PDF]

Nanoscale Adv
Mohammad SI, Jabbar HS, Vasudevan A, Sapaev IB, Rekha MM, Gayathri S, Zabebah H, Sharma R, Samantsinghar P, Mahmoodi S.   +9 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Exploiting negative photochromism to harness a four-photon-like fluorescence response with two-photon excitation. [PDF]

Nat Commun
Benitez-Martin C, Rouillon J, Fron E, de Jong F, Grøtli M, Hofkens J, Pischel U, Andréasson J.   +7 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Is seeing believing?-signal differentiation in a preclinical transbronchial imaging study implementing a composite optical fiber bronchoscope to detect a folate receptor-targeted near-infrared fluorophore. [PDF]

Transl Lung Cancer Res
Hiraishi Y, Ishiwata T, Husby T, Sata Y, Gregor A, Koga T, Ogawa H, Kitazawa S, Yokote F, Aragaki M, Kazlovich K, Effat A, Bernards N, Kage H, Wilson BC, Yasufuku K.   +15 more
europepmc   +1 more source