Results 281 to 290 of about 215,411 (342)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

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Detection of oxygen by fluorescence quenching

Applied Optics, 1985
The incorporation of an aromatic hydrocarbon fluorescent compound into silicone allows utilization of fluorescence quenching as a mechanism to measure molecular oxygen concentration in the composite matrix. Excitation and emission spectra of the aromatics change in agreement with the Franck-Condon model when the universal solvent is benzene ...
M E, Cox, B, Dunn
openaire   +2 more sources

Fluorescence quenching of acridines by strandin

Archives of Biochemistry and Biophysics, 1961
Abstract The interaction of four acridine compounds with strandin has been studied, with special attention being directed to acriflavine. In all cases fluorescence quenching by strandin occurs, the nature of the quenching curve depending on the dye involved.
A F, HARRIS, A, SAIFER, S K, WEINTRAUB
openaire   +2 more sources

Fluorescence quenching of tryptophan by trifluoroacetamide

Biochimica et Biophysica Acta (BBA) - General Subjects, 1984
Trifluoroacetamide was found to be a good quencher of tryptophan fluorescence, and the quenching was shown to proceed via both a dynamic and a static process. The respective quenching constants were determined by the measurement of the decrease of the fluorescence lifetime in the presence of the quencher.
Midoux, Patrick, Wahl, Philippe, Auchet, Jean-Claude, Monsigny, Michel   +3 more
openaire   +3 more sources

Quenching of chlorophyll fluorescence by quinones

IUBMB Life, 1998
AbstractQuinones caused quenching of Chl a fluorescence in native and model systems. Menadione quenched twofold the fluorescence of Chl a and BChl a in pea chloroplasts, chromatophores of purple bacteria, and liposomes at concentrations of 50‐80 μM. To obtain twofold quenching in Triton X‐100 micelles and in ethanol, the addition of 1.3 mM and 11 mM ...
V D, Samuilov, , Borisov AYu, E L, Barsky, O F, Borisova, A V, Kitashov   +4 more
openaire   +2 more sources

Fluorescence Quenching in Membrane Phase

Biochemical and Biophysical Research Communications, 1995
Membrane-related events can be investigated when the fluorescence of an intramembrane fluorophore is quenched by molecules that are dissolved in lipid phase. In this case the bimolecular quenching constant characterises the relative transport rate of the fluorophore and quencher molecules in the membrane interior and thereby it is related to the ...
Z, Lakos, A, Szarka, B, Somogyi
openaire   +2 more sources

Fluorescence quenching studies with proteins

Analytical Biochemistry, 1981
Abstract A review is presented on the use of the technique of solute fluorescence quenching to study the structure and dynamics of proteins. A number of factors are discussed that must be considered in analyzing such data. Among these factors are the efficiency of the quenching process, the relative importance of static quenching, the heterogeneity ...
M R, Eftink, C A, Ghiron
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On mechanisms of fluorescence quenching by water

Biophysics, 2014
Mechanisms of fluorescence quenching of aromatic chromophores by water are reviewed. The mechanisms include polarity of chromophore environment, proton or electron transfer between the excited chromophore and water. A hypothesis is proposed that the quenching can be a result of chromophore-solvent hydrogen bond breaking in the excited state.
G E, Dobretsov, T I, Syrejschikova, N V, Smolina   +2 more
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Steric effect on fluorescence quenching

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005
In this communication we have reported the steric effect on the fluorescence quenching rate constants of the electron transfer (ET) process. We have done a comparative study using donor (D)-acceptor (A) systems with different exergonicity (-deltaG(f)). Different carbazole derivatives (CZ): 1,4-dicyanobenzene (DCB) systems (-deltaG(f) = 0.7-0.8 eV) were
Suchandra, Chatterjee, Samita, Basu, Nandita, Ghosh, Manas, Chakrabarty   +3 more
openaire   +2 more sources