Results 71 to 80 of about 767,670 (302)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Comparative Studies on the Interaction of Cochinchinenin A and Loureirin B with Bovine Serum Albumin

open access: yesJournal of Spectroscopy, 2013
This paper describes the simple, sensitive, and effective spectrophotometric methods based on ultraviolet, fluorescence and circular dichroism for revealing the interactional mechanism of Cochinchinenin A (CA) and Loureirin B (LB) with bovine serum ...
Tianming Yang   +6 more
doaj   +1 more source

Comparison of Anionic, Cationic and Nonionic Surfactants as Dispersing Agents for Graphene Based on the Fluorescence of Riboflavin

open access: yesNanomaterials, 2017
Fluorescence quenching is a valuable tool to gain insight about dynamic changes of fluorophores in complex systems. Graphene (G), a single-layered 2D nanomaterial with unique properties, was dispersed in surfactant aqueous solutions of different nature ...
Rocío Mateos   +4 more
doaj   +1 more source

Fluorescence Enhancement and Quenching in Tip-Enhanced Fluorescence Spectroscopy

open access: yesFrontiers in Optics / Laser Science, 2018
We study fluorescence enhancement for a dipole emitter placed between a tip and different dielectric substrates. Resonant behavior is observed as a function of tip-substrate distance for a silver tip placed above a glass substrate and displays a strong dependence on the radius of the curvature of the tip.
Justin R. Isaac, Huizhong Xu
openaire   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

Kinetic models of photosystem II should accommodate the effect of donor side quenching on variable chlorophyll a fluorescence in the microseconds time [PDF]

open access: yes, 2009
Quantitative data on laser flash-induced variable fluorescence in the 100 ns to 1 ms time range (Belyaeva et al. in Photosynth Res 98:105–119, 2008) confirming those of others (Steffen et al.
Wim J. Vredenberg, Vredenberg, W.J.
core   +1 more source

Phytoplankton adaptation to marine ecosystems: insights into photophysiological functional diversity [PDF]

open access: yes, 2011
The aim of this study was to investigate the diversity of the photoprotective responses activated by phytoplankton at short temporal scales, i.e. the non-photochemical quenching of Chl a fluorescence (NPQ) associated with the xanthophyll cycle (XC ...
Giovagnetti, Vasco
core   +1 more source

Fluorescent carbon dioxide indicators [PDF]

open access: yes, 2005
Over the last decade, fluorescence has become the dominant tool in biotechnology and medical imaging. These exciting advances have been underpinned by the advances in time-resolved techniques and instrumentation, probe design, chemical / biochemical ...
Hodgen, S., Mills, A.
core   +2 more sources

Synthesis and photophysical studies on 5-ethoxycarbonyl-4-cinnamyl-6-methyl-3,4-dihydropyrimidine-2(1H)-one in various solvents

open access: yesBulletin of the Chemical Society of Ethiopia, 2009
The 5-ethoxycarbonyl-4-cinnamyl-6-methyl-3,4-dihydropyrimidine-2(1H)-one (DHPM) was synthesized via Biginelli reaction and was characterized by NMR, IR, UV−Visible absorption and fluorescence spectroscopy.
Sheela N. Lad   +4 more
doaj  

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy