Results 91 to 100 of about 513,540 (340)

Fluorescence strategies for mapping cell membrane dynamics and structures

APL Bioengineering, 2020
Fluorescence spectroscopy has been a cornerstone of research in membrane dynamics and organization. Technological advances in fluorescence spectroscopy went hand in hand with discovery of various physicochemical properties of membranes at nanometric ...
Jagadish Sankaran, Thorsten Wohland
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Optical Coherence Tomography, Near‐Infrared Spectroscopy, and Near‐Infrared Fluorescence Molecular Imaging

, 2022
Alessio Mattesini, Pierluigi Demola, Richard Shlofmitz, Evan Shlofmitz, Ron Waksman, Farouc A. Jaffer, Carlo Di Mario   +6 more
openalex   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Experimental access to higher-order Zeeman effects by precision spectroscopy of highly charged ions in a Penning trap

, 2013
We present an experimental concept and setup for laser-microwave double-resonance spectroscopy of highly charged ions in a Penning trap. Such spectroscopy allows a highly precise measurement of the Zeeman splittings of fine- and hyperfine-structure ...
Birkl, G., Glazov, D. A., Martin, A., Plunien, G., Quint, W., Shabaev, V. M., Sokolov, M. M., Vogel, M., Volotka, A. V., von Lindenfels, D., Wiesel, M.   +10 more
core   +1 more source

Impact of Pre‐Oxidation Treatments on a Recycled MgO/Steel‐Composite as Carbon Free Anode in Aluminum‐Electrolysis Environments

Advanced Engineering Materials, EarlyView.
Cermets (60 vol.% AISI 316L stainless steel, 40 vol.% recycled MgO), intended for use in aluminum electrolysis, were pre‐oxidized in three furnaces with different heating technologies and subjected to a cryolite corrosion test. The different atmospheres influenced the formation of oxide layers, which in turn affected corrosion resistance and ...
Patricia Kaiser, Felix Drechsler, Nora Brachhold, Florian Kerber, Christos G. Aneziris   +4 more
wiley   +1 more source

Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe

, 2013
We present an ex vivo study of temporally and spectrally resolved autofluorescence in a total of 47 endoscopic excision biopsy/resection specimens from colon, using pulsed excitation laser sources operating at wavelengths of 375 nm and 435 nm.
Chorvat, Chwirot, Chwirot, Cothren, Cothren, Cross, Curvers, De Beule, Drezek, Duraipandian, Eker, Fang, Georgakoudi, Georgakoudi, Glanzmann, Gono, Hilska, Hotouras, Huang, Jo, Kapadia, Kara, Kiesslich, Lambert, Li, Lin, Lovat, Maarek, Manning, Marcu, Mayinger, Mayinger, Mayinger, McGinty, Mizeret, Mycek, Nakaniwa, Nakashima, Palero, Palmer, Pfefer, Pitts, Ramanujam, Rex, Richards-Kortum, Schomacker, Schomacker, Schweitzer, Shao, Shim, Skala, Taplin, Thompson, Vishwasrao, Vogelstein, Wagnières, Wallace, Wang, Williams, Xiao, Yang, Zhuo, Zhuo, Zhuo, Zhuo, Zonios   +65 more
core   +1 more source

Hydrogen‐Assisted Fracture of Iron‐Based Fe–Ni–Al Alloys

Advanced Engineering Materials, EarlyView.
Principal relations and fracture mechanisms of single‐phase and precipitate‐strengthened Fe–Ni–Al alloys subjected to prior electrochemical hydrogen charging are identified. The mechanisms of hydrogen effect on strength and microhardness are discussed, including hydrogen‐induced increase in microhardness and the role of hydrogen in fracture behavior ...
Nataliya Yadzhak, Olha Zvirko, Rostyslav Leshchak, Hryhoriy Nykyforchyn   +3 more
wiley   +1 more source

Fluorescence Analysis for Multi-Site Aluminum Binding to Natural Organic Matter [PDF]

, 1998
Natural organic matter (NOM) samples isolated from different water sources in Norway were compared using their fluorescence properties. Fluorescence surfaces were observed at pH 4.36 and deconvoluted using SIMPLISMA (Windig and Guilment 1991). There were
Kramer, James R., Smith, D. Scott
core   +1 more source