Results 61 to 70 of about 182,643 (277)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comparison between a direct-flow SPR immunosensor for ampicillin and a competitive conventional amperometric device: analytical features and possible applications to real samples [PDF]

, 2017
In this research, we developed a direct-flow surface plasmon resonance (SPR) immunosensor for ampicillin to perform direct, simple, and fast measurements of this important antibiotic.
Campanella, Luigi, Favero, Gabriele, Martini, Elisabetta, Mazzei, Franco, Merola, Giovanni, Sanzo', Gabriella, Tomassetti, Mauro   +6 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reproducibility of Clinico-histopathological Findings by Direct Immunofluorescence of Fixed, Paraffin Embedded Tissue Specimens for Diagnosis of Lichen Planus

Journal of Islamic Dental Association of Iran, 2015
Background and Aim: Lichen planus (LP) is a chronic mucocutaneous disorder mediatd by the impaired immunity, in which the association of clinical and histopathological findings is necessary for a definite diagnosis.
Ali Reza Ghannadan, Maryam Seyedmajidi, Sara Mehrabi, Ozra Abdolabadi, Pouyan Aminishakib, Ali Bijani   +5 more
doaj  

Demonstração por imunofluorescência direta de antígenos do vírus da febre amarela em tecido hepático pré-tratado com tripsina Direct immunofluorescence demonstration of yellow fever antigens in hepatic tissue pretreated with trypsin

Memorias do Instituto Oswaldo Cruz, 1984
Neste trabalho descreve-se uma prova de imunofluorescência direta (IFD), com o mesmo material de fragmentos de tecido hepático, fixados em formol, obtidos de casos suspeitos de infecção por febre amarela e utilizados para a histopatologia; um conjugado ...
Hermann Gonçalves Schatzmayr, Ortrud Monika Barth, Alexandre Alberto de Alencar   +2 more
doaj   +1 more source

Fluorescent Antibodies Applied to Direct Epifluorescent Filter Technique for Microscopic Enumeration of Escherichia coli 0157:H7 in Milk and Juice

Journal of Food Protection, 1993
In a modification of the direct epifluorescent filter technique (DEFT), direct fluorescent antibody staining was used for the rapid (
Mary L, Tortorello, Steven M, Gendel
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Nanopipettes as Monitoring Probes for the Single Living Cell: State of the Art and Future Directions in Molecular Biology. [PDF]

, 2018
Examining the behavior of a single cell within its natural environment is valuable for understanding both the biological processes that control the function of cells and how injury or disease lead to pathological change of their function.
Bulbul, Gonca, Chaves, Gepoliano, Olivier, Joseph, Ozel, Rifat Emrah, Pourmand, Nader   +4 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source