Results 171 to 180 of about 53,983 (253)

A Highly Specific Antibody-Based Assay for <i>Nipah</i> Virus AlphaLISA Detection. [PDF]

Viruses
Sun X, Lv Q, Huang W, Zhang X, Duan H, Ren Y, Zhang X, Jiang Y, Zhao R, Chen S.   +9 more
europepmc   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I): Antibodies to Intracellular Antigens. [PDF]

Neurol Neuroimmunol Neuroinflamm
Milano C, Businaro P, Papi C, Arlettaz L, Marmolejo L, Naranjo L, Gastaldi M, Iorio R, Saiz A, Planagumà J, Aguilar E, Pizzanelli C, Martinez-Hernandez E, Armangué T, Guasp M, Ruiz-García R, Sabater L, Dalmau JO, Graus F, Spatola M.   +19 more
europepmc   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, EarlyView.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source

Acoustic Field Enabled Polymeric Nanoparticle Deposition onto Vessel Walls for Enhanced Drug Delivery. [PDF]

Nano Lett
Wu J, Zhao L, Dubrunfaut EH, Lallo VA, Chen S, Wu Q, Li B, Bracaglia LG.   +7 more
europepmc   +1 more source

Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis

Advanced Science, EarlyView.
Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart, Alanna G. Spiteri, Jian Tan, Laurence Macia, Nicholas J. C. King   +4 more
wiley   +1 more source

Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury

Advanced Science, EarlyView.
This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong, Liang Zhao, Xianzheng Sang, Chao Ma, Meiqi Chang, Xinran Song, Wei Feng, Tao Xu, Li Ding, Yu Chen, Lijun Hou   +10 more
wiley   +1 more source

ADCC: the rock band led by therapeutic antibodies, tumor and immune cells. [PDF]

Front Immunol
Vincken R, Armendáriz-Martínez U, Ruiz-Sáenz A.   +2 more
europepmc   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

High resolution capillary western blot analysis of antibody reactivity in human visceral leishmaniasis. [PDF]

Rev Inst Med Trop Sao Paulo
Silva MVD, Matos A, Oliveira RF, Silva JRME, Santos-Obata MM, Silva-Teixeira LA, Correa-Filho D, Rodrigues DBR, Rodrigues Junior V.   +8 more
europepmc   +1 more source