Results 71 to 80 of about 142,953 (264)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Case for diagnosis Caso para diagnóstico

Anais Brasileiros de Dermatologia, 2012
We report a clinical case of a rare variant of pemphigus - pemphigus herpetiformis - which combines the clinical features of dermatitis herpetiformis with the immunological findings of pemphigus.
Iolanda Conde Fernandes, Madalena Sanches, Rosário Alves, Manuela Selores   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Análise de exames de imunofluorescência direta para o diagnóstico de tracoma

Revista de Saúde Pública
Para confirmação de foco de tracoma em locais onde não existiam casos anteriormente relatados, a Secretaria de Estado da Saúde preconiza a realização de exames laboratoriais principalmente pelo fato da doença ter sido considerada erradicada no Estado de ...
Norma H. Medina, Rosana M. Gentil, Márcia Caraça, César K. Suzuki, Heloísa H. B. Melles   +4 more
doaj  

Expression and significance of p120ctn isoforms in lung squamous cell carcinomas

Chinese Journal of Lung Cancer, 2008
Background and Objective It has been proven that p120ctn plaied an important role in cell adhesion and correlates with tumorigenesis significantly, the aim of this work is to investigate the expression of p120ctn(p120 catenin) isoform proteins in lung ...
Enhua WANG, Yan WANG, Yang LIU, Yuan MIAO   +3 more
doaj  

American cutaneous leishmaniasis in dogs from an endemic urban area in Cianorte municipality, Paraná State, Brazil

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
American cutaneous leishmaniasis (ACL) was investigated in dogs from an urban endemic area in Cianorte, Paraná state, Brazil. Of 169 studied dogs, none presented suspected ACL lesions.
DA Cerino, J Veloso, TF Perles, PD Zanzarini, MVC Lonardoni, TGV Silveira   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Preliminary Study of In Vivo Formed Dental Plaque Using Confocal Microscopy and Scanning Electron Microscopy

Frontiers in Dentistry, 2009
Objective: Confocal laser scanning microscopy (CLSM) is relatively a new light microscopical imaging technique with a wide range of applications in biological sciences. primary value of CLSM for the biologist is its ability to provide optical sections
KA. Al-Salihi , NABA. Tarmidzi   +1 more
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Evaluación de la prueba de inmunofluorescencia indirecta para el diagnóstico de leptospirosis humana.

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. El diagnóstico de la leptospirosis es difícil debido al amplio espectro de síntomas clínicos que presenta. Varias pruebas diagnósticas serológicas se han desarrollado, pero su aplicación y utilidad en Colombia no han sido determinadas ...
Piedad Agudelo Flórez, Marcos Restrepo, María Amparo Lotero   +2 more
doaj   +1 more source