Results 71 to 80 of about 144,270 (311)

Confocal laser scanning microscopy of nanoparticles applied to immunosorbent assays

, 2011
The aim of this project was to demonstrate and develop a confocal readout method for fluorescent immunosorbent assays and investigate its potential advantages in comparison to traditional immunoassays.
Ghafari, H
core  

LOCALIZATION OF MYOGLOBIN IN HUMAN SKELETAL MUSCLE USING FLUORESCENT ANTIBODY TECHNIQUE

, 1967
Rabbit antiserum to human myoglobin was used with the indirect fluorescent antibody technique to localize this protein in human skeletal muscle.
LAWRENCE J. KAGEN, RAYA GUREVICH
core   +1 more source

Screening programmes for the early detection and prevention of oral cancer [PDF]

, 2010
Background Oral cancer is an important global healthcare problem, its incidence is increasing and late-stage presentation is common. Screening programmes have been introduced for a number of major cancers and have proved effective in their early ...
Richard Oliver, Oliver, Richard, Sloan, Philip, Omar Kujan, Ogden, Graham; id_orcid, Graham Ogden, Anne-Marie Glenny, Paul Brocklehurst, Kujan, Omar, Simon Shepherd, Brocklehurst, Paul, Glenny, Anne-Marie, Philip Sloan, Shepherd, Simon   +13 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core   +1 more source

Reproducibility of Clinico-histopathological Findings by Direct Immunofluorescence of Fixed, Paraffin Embedded Tissue Specimens for Diagnosis of Lichen Planus

Journal of Islamic Dental Association of Iran, 2015
Background and Aim: Lichen planus (LP) is a chronic mucocutaneous disorder mediatd by the impaired immunity, in which the association of clinical and histopathological findings is necessary for a definite diagnosis.
Ali Reza Ghannadan, Maryam Seyedmajidi, Sara Mehrabi, Ozra Abdolabadi, Pouyan Aminishakib, Ali Bijani   +5 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Influence of fluorescent antibody probe specificity on flow cytometric analysis of antibody-producing cells

, 1996
In the flow cytometric analysis of the stability of antibody-producing cells, fluorescent antibody probes specific for immunoglobulin heavy chains have been widely utilized to quantify intracellular antibodies.
Lee, Gyun-Min, Bae, SW
core   +1 more source

Expression and significance of p120ctn isoforms in lung squamous cell carcinomas

Chinese Journal of Lung Cancer, 2008
Background and Objective It has been proven that p120ctn plaied an important role in cell adhesion and correlates with tumorigenesis significantly, the aim of this work is to investigate the expression of p120ctn(p120 catenin) isoform proteins in lung ...
Enhua WANG, Yan WANG, Yang LIU, Yuan MIAO   +3 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source