Results 71 to 80 of about 4,611,335 (254)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Reproducibility of Clinico-histopathological Findings by Direct Immunofluorescence of Fixed, Paraffin Embedded Tissue Specimens for Diagnosis of Lichen Planus

Journal of Islamic Dental Association of Iran, 2015
Background and Aim: Lichen planus (LP) is a chronic mucocutaneous disorder mediatd by the impaired immunity, in which the association of clinical and histopathological findings is necessary for a definite diagnosis.
Ali Reza Ghannadan, Maryam Seyedmajidi, Sara Mehrabi, Ozra Abdolabadi, Pouyan Aminishakib, Ali Bijani   +5 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Case for diagnosis Caso para diagnóstico

Anais Brasileiros de Dermatologia, 2012
We report a clinical case of a rare variant of pemphigus - pemphigus herpetiformis - which combines the clinical features of dermatitis herpetiformis with the immunological findings of pemphigus.
Iolanda Conde Fernandes, Madalena Sanches, Rosário Alves, Manuela Selores   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Localisation of tissue antigens with the fluorescent antibody technique: studies on connective tissue, the kidney and anterior pituitary hormones [PDF]

, 1958
Problems involved in the use of the fluorescent antibody technique for the localisation of tissue components are discussed. The need for pure tissue extracts for the immunisation of animals is emphasised and some of the dangers of extraction ...
Cruickshank, Bruce
core   +3 more sources

Should We Adopt Increased Dilutions for Indirect Immunofluorescence in Pediatric Anti-Centromere Antibody Testing? Insights from a Three-Year Retrospective Study

Children
Background/Objectives: Systemic autoimmune rheumatic diseases (SARDs) pose diagnostic challenges, particularly in pediatric populations, due to their diverse presentations and overlapping symptoms.
Mehmet Soylu, Raziye Burcu Taşkın, Gülçin Aytaç, Güzide Aksu, Seyfi Durmaz, Miray Karakoyun, Şaziye Rüçhan Sertöz   +6 more
doaj   +1 more source

American cutaneous leishmaniasis in dogs from an endemic urban area in Cianorte municipality, Paraná State, Brazil

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
American cutaneous leishmaniasis (ACL) was investigated in dogs from an urban endemic area in Cianorte, Paraná state, Brazil. Of 169 studied dogs, none presented suspected ACL lesions.
DA Cerino, J Veloso, TF Perles, PD Zanzarini, MVC Lonardoni, TGV Silveira   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

LOCALIZATION OF SKELETAL MUSCLE PHOSPHORYLASE USING A FLUORESCENT ANTIBODY TECHNIQUE AND ITS CORRELATION WITH HISTOCHEMICAL OBSERVATIONS

, 1965
The Coons fluorescent antibody technique was employed to localize rabbit muscle phosphorylase within striated muscle cells. Pooled sera from guinea pigs sensitized against 2X crystallized rabbit phosphorylase a in complete Freund's adjuvant gave a ...
RICHARD B. COHEN, HAROLD F. DVORAK
core   +1 more source