Results 241 to 250 of about 210,311 (310)

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li   +9 more
wiley   +1 more source

Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X‐ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights ...
Rosalía López‐Méndez   +11 more
wiley   +1 more source

Engineered In Vitro Multi‐Cell Type Ventricle Model Generates Long‐Term Pulsatile Flow and Modulates Cardiac Output in Response to Cardioactive Drugs

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents an innovative in vitro model of a human left ventricle using biofunctionalized PDMS membranes and human iPSC‐derived cardiomyocytes. The engineered ventricle demonstrates stable, long‐term pulsatile flow, and physiological responses to cardioactive drugs.
Christoph Kuckelkorn   +6 more
wiley   +1 more source

Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model

open access: yesAdvanced Healthcare Materials, EarlyView.
This study developed a biomimetic scaffold incorporating PDRN and melatonin to restore ovarian function in chemotherapy‐induced premature ovarian insufficiency, enhancing cell survival, folliculogenesis, and hormone normalization, while improving fertility rates and offspring in a mouse model, offering a promising strategy for ovarian function ...
Da‐Seul Kim   +8 more
wiley   +1 more source

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