Results 231 to 240 of about 1,158,324 (307)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Correction to 'Retraction of 'Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe''. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Porphyrin-Based Fluorescent Probe for Nanomolar Detection of Cu²⁺ and Ni²⁺ Ions. [PDF]

Molecules
Shin SH, Kim J, Moon H, Sheshashena Reddy T, Choi MS.   +4 more
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

SiR-XActin: A Fluorescent Probe for Imaging Actin Dynamics in Live Cells. [PDF]

Angew Chem Int Ed Engl
Nasufovic V, Kompa J, Lindamood HL, Blümke M, Dibsy R, Koch B, Levario-Diaz V, Weber K, Maager M, Nomerotskaia E, Echard A, Cavalcanti-Adam EA, Vitriol EA, Arndt HD, Johnsson K.   +14 more
europepmc   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Retraction of 'Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

A fluorescent probe under the microscope showing dual recognition of B-DNA and G-quadruplex DNA. [PDF]

Commun Chem
Gramolini L, López-Corbalán R, Marazzi M, García-Iriepa C.   +3 more
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Real-Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe. [PDF]

Adv Sci (Weinh)
Sarkar S, Shil A, Jun YW, Yang YJ, Cheng R, Wu W, Li X, Hu Q, Ahn KH.   +8 more
europepmc   +1 more source