Results 221 to 230 of about 789,313 (250)

Genetically encoded fluorescent probes to assist in the diagnosis of small cell lung cancer. [PDF]

Appl Microbiol Biotechnol
Xu D, Yuan H, Li Z, Jiang Q, Shang A, Liu J, Xue C, Shao S, Zhang H, Wu B, Liu B.   +10 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Recent Progress in Peptide-Based Fluorescent Probes Biomedical Applications: A Review. [PDF]

Int J Nanomedicine
Zhong X, Xie Y, Chen Y, Lu Y, Hou M.
europepmc   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Late-Stage Functionalization of Lysine to Organelle-Targeting Fluorescent Probes. [PDF]

JACS Au
Rodriguez P, Misra A, Raj M.
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Electrochemical synthesis of Betti bases and their application as fluorescent probes for Hg²⁺ ions. [PDF]

BMC Chem
El-Khouly EA, Mahmoud AM, El-Nassan HB.
europepmc   +1 more source

Advancements and perspectives on organelle-targeted fluorescent probes for super-resolution SIM imaging. [PDF]

Chem Sci
Li G, Ge E, Zheng H, Lin W.
europepmc   +1 more source

Mitochondria-Targeted Quinoline-Based Fluorescent Probes for Imaging of Viscosity and MAO‑A with High-Throughput Inhibitor Screening. [PDF]

Chem Biomed Imaging
Luo X, Li L, Zeng Y, Li Z, Sun M, Zhong Y, Qian Y.   +6 more
europepmc   +1 more source

Single Mitochondrion Morphology-Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence. [PDF]

Adv Sci (Weinh)
Ding Y, Fang B, Li Q, Zhang B, Li J, Bai H, Voelcker NH, Peng B, Yang X, Li L.   +9 more
europepmc   +1 more source