Results 261 to 270 of about 1,322,177 (348)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A highly photostable monomeric red fluorescent protein for dual-color 3D STED and time-lapse 3D SIM imaging. [PDF]

Nat Methods
Ding Y, He W, Wang K, Xue F, Zheng K, Zhao S, Qi D, Li T, Xia P, Pan L, Chen L, Chen Z, Yuan L, Xu P.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

[Expression of Concern] Establishment and evaluation of a new highly metastatic tumor cell line 5a‑D‑Luc‑ZsGreen expressing both luciferase and green fluorescent protein. [PDF]

Int J Oncol
Sudo H, Tsuji AB, Sugyo A, Takuwa H, Masamoto K, Tomita Y, Suzuki N, Imamura T, Koizumi M, Saga T.   +9 more
europepmc   +1 more source

Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins

, 2015
Dmytro Dziuba, Radek Pohl, Michal Hocek
openalex   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Single-cell analysis of yeast surface display for designer cellulosome applications using a fluorescent protein complex. [PDF]

Microbiol Spectr
Lamote B, Cremelie E, Demeyere K, De Groote P, Grimon D, Vanderstraeten J, Meyer E, De Mey M, Briers Y.   +8 more
europepmc   +1 more source

Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter [PDF]

Thomas R. Mumford, Diarmid Rae, Emily Brackhahn, Abbas Idris, David Gonzalez-Martinez, Ayush Aditya Pal, Michael C. Chung, Juan Guan, Elizabeth Rhoades, Lukasz J. Bugaj   +9 more
openalex   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Improved RSV Neutralization Assay Using Recombinant RSV Expressing Reporter Fluorescent Protein. [PDF]

Methods Protoc
Yamagata Y, Toizumi M, Eleouet JF, Rameix-Welti MA, Takeda M, Yoshida LM.   +5 more
europepmc   +1 more source