Results 11 to 20 of about 49,486 (246)

PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[¹⁸F]fluoro-6-deoxy-D-fructose

Molecules, 2022
Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[18F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed predominantly in brain microglia and activated in response to inflammatory stimuli.
Amanda J. Boyle, Emily Murrell, Junchao Tong, Christin Schifani, Andrea Narvaez, Melinda Wuest, Frederick West, Frank Wuest, Neil Vasdev   +8 more
doaj   +1 more source

Importance of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in detection of post-thyroidectomy recurrence in differentiated thyroid cancer with negative radio-isotope iodine scan, yet, elevated serum thyroglobulin level

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background Thyroid cancer considered the 6th common cancer in female and represents approximately 1% of all cancers. Thyroid cancer is generally characterized by good prognosis, long term survival and low aggressiveness. Its prognosis is related to tumor
Amir Fathy Henfy Younis, Ahmed Farid Yousif, Hamada Mohamed Khater   +2 more
doaj   +1 more source

Methods to Increase the Metabolic Stability of 18F-Radiotracers

Molecules, 2015
The majority of pharmaceuticals and other organic compounds incorporating radiotracers that are considered foreign to the body undergo metabolic changes in vivo.
Manuela Kuchar, Constantin Mamat
doaj   +1 more source

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoro­ethoxylerianin, an 18F-Labeled Erianin Analogue

SynOpen, 2022
Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie, Nian Wang, Jinwen Huang, Zhuang Ni, Kangyan Xue, Lixing Song, Mingwei Wang, Fanhong Wu   +7 more
doaj   +1 more source

Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

EJNMMI Research, 2020
Introduction Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68Ga]Gallium, [177Lu]Lutetium ...
Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo, Hans-Jürgen Wester   +8 more
doaj   +1 more source

Fully Automated GMP-Compliant Synthesis of [¹⁸F]FE-PE2I

Pharmaceuticals, 2021
In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ...
Klas Bratteby, Charlotte Lund Denholt, Szabolcs Lehel, Ida Nymann Petersen, Jacob Madsen, Maria Erlandsson, Tomas Ohlsson, Matthias Manfred Herth, Nic Gillings   +8 more
doaj   +1 more source

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides)

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +1 more source

Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design

Frontiers in Chemistry, 2022
The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects.
Yunze Wang, Yunze Wang, Yunze Wang, Qingyu Lin, Qingyu Lin, Qingyu Lin, Hongcheng Shi, Hongcheng Shi, Hongcheng Shi, Dengfeng Cheng, Dengfeng Cheng, Dengfeng Cheng   +11 more
doaj   +1 more source

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

EJNMMI Radiopharmacy and Chemistry, 2022
Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics.
Carsten Sven Kramer, Luca Greiner, Klaus Kopka, Martin Schäfer   +3 more
doaj   +1 more source

Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2

Molecules, 2022
Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer.
Jatinder Kaur, Atul Bhardwaj, Frank Wuest   +2 more
doaj   +1 more source