Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
Angewandte Chemie International Edition, 2011 Positron (b) emission tomography (PET) is a powerful, noninvasive tool for the in vivo, three-dimensional imaging of physiological structures and processes. PET imaging involves the incorporation of short-lived radionuclides, particularly carbon-11 and fluorine-18, into biologically active molecules.
Littich, Ryan, Scott, Peter J. H.
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A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions. [PDF]
Chemistry, 2017 Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents.
M. Klenner +10 more
semanticscholar +3 more sources
Fluorine-18 incorporation and radiometal coordination in macropa ligands for PET imaging and targeted alpha therapy. [PDF]
Chem Commun (Camb)The development of theranostic agents for radiopharmaceuticals based on therapeutic alpha emitters marks an important clinical need. We describe a strategy for the development of theranostic agents of this type via the functionalization of the ligand ...
Kanagasundaram T +5 more
europepmc +3 more sources
Molecules, 2021 In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang +4 more
doaj +1 more source
State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis
EJNMMI Radiopharmacy and Chemistry, 2023 Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis.
Lizeth Y. F. Haveman +2 more
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Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non–small‐cell lung cancer patients [PDF]
International Journal of Cancer, 2012 Yihua Wu +8 more
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Fully Automated, High-Dose Radiosynthesis of [18F]PARPi
Pharmaceuticals, 2022 [18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli +9 more
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Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging
Pharmaceuticals, 2022 Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud +9 more
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
ACS Chemical Neuroscience, 2020 Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets.
S. Syvänen +7 more
semanticscholar +1 more source
Advances in [18F]Trifluoromethylation Chemistry for PET Imaging
Molecules, 2021 Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo.
Felix Francis, Frank Wuest
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