Results 11 to 20 of about 3,321,367 (333)
Molecules, 2021 In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang +4 more
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State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis
EJNMMI Radiopharmacy and Chemistry, 2023 Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis.
Lizeth Y. F. Haveman +2 more
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Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging
Pharmaceuticals, 2022 Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud +9 more
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Fully Automated, High-Dose Radiosynthesis of [18F]PARPi
Pharmaceuticals, 2022 [18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli +9 more
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Advances in [18F]Trifluoromethylation Chemistry for PET Imaging
Molecules, 2021 Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo.
Felix Francis, Frank Wuest
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Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
Angewandte Chemie International Edition, 2011 Positron (b) emission tomography (PET) is a powerful, noninvasive tool for the in vivo, three-dimensional imaging of physiological structures and processes. PET imaging involves the incorporation of short-lived radionuclides, particularly carbon-11 and fluorine-18, into biologically active molecules.
Littich, Ryan, Scott, Peter J. H.
openaire +3 more sources
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
ACS Chemical Neuroscience, 2020 Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets.
S. Syvänen +7 more
semanticscholar +1 more source
Pharmaceuticals, 2022 High expression of prostate-specific membrane antigen (PSMA) in prostate cancers prompted the development of the PSMA-targeted PET-imaging agent [18F]DCFPyL, which was recently approved by the FDA. Fluorine-18-labeled Lys–Urea–Glu-based oxime derivatives
Falguni Basuli +7 more
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The Egyptian Journal of Radiology and Nuclear Medicine, 2022 Background Thyroid cancer considered the 6th common cancer in female and represents approximately 1% of all cancers. Thyroid cancer is generally characterized by good prognosis, long term survival and low aggressiveness. Its prognosis is related to tumor
Amir Fathy Henfy Younis +2 more
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Molecules, 2022 Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[18F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed predominantly in brain microglia and activated in response to inflammatory stimuli.
Amanda J. Boyle +8 more
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