Results 21 to 30 of about 61,677 (335)

Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis [PDF]

, 2016
There is currently no ideal radiotracer for imaging protein synthesis rate (PSR) by positron emission tomography (PET). Existing fluorine-18 labelled amino acid-based radiotracers predominantly visualize amino acid transporter processes, and in many ...
Alan C. Perkins, Carmen Tong, Franklin I. Aigbirhio, Helen M. Betts, Ishiwata K., Lampinen J., Philip J. Hill, Ramla O. Awais, Selena Milicevic Sephton   +8 more
core   +3 more sources

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoro­ethoxylerianin, an 18F-Labeled Erianin Analogue

SynOpen, 2022
Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie, Nian Wang, Jinwen Huang, Zhuang Ni, Kangyan Xue, Lixing Song, Mingwei Wang, Fanhong Wu   +7 more
doaj   +1 more source

Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

EJNMMI Research, 2020
Introduction Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68Ga]Gallium, [177Lu]Lutetium ...
Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo, Hans-Jürgen Wester   +8 more
doaj   +1 more source

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]

, 2016
We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N., O’Hagan, David, Thompson, Stephen   +2 more
core   +1 more source

Fully Automated GMP-Compliant Synthesis of [¹⁸F]FE-PE2I

Pharmaceuticals, 2021
In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ...
Klas Bratteby, Charlotte Lund Denholt, Szabolcs Lehel, Ida Nymann Petersen, Jacob Madsen, Maria Erlandsson, Tomas Ohlsson, Matthias Manfred Herth, Nic Gillings   +8 more
doaj   +1 more source

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography [PDF]

, 2008
The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor ...
Bergstr  m, Burns, Chou, D. A. Harki, D. B. Stout, Dervan, Dervan, Dudouet, Edelson, Gross, Harapanhalli, Hsu, K  hnast, Lee, Lendvai, M. E. Phelps, N. Satyamurthy, P. B. Dervan, Phelps, Phelps, Poethko, Puckett, Roivainen, Schottelius, Tavitian, Toyokuni, Trauger   +26 more
core   +3 more sources

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) [PDF]

, 2011
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT
A Katagiri, B Levin, BR Weston, CD Johnson, CG Fraser, D Ravizza, D Thorwarth, DF Halpenny, Eisuke Kaji, EM Kamel, EM Rohren, F Gutman, FA Sinicrope, H Pohl, Hideyuki Suzuki, J Czernin, JP Drenth, Jun Kato, Kazuhide Yamamoto, Keisuke Hori, KS Tagore, MB Tessem, MC Kouwen van, Mitsuhiro Akita, O Israel, PL Kei, R Meza, R Minamimoto, R Tatlidil, Reiji Higashi, S Friedland, S Halligan, S Kudo, S Kudo, S Tsuda, S Yasuda, Sakiko Hiraoka, Sakuma Takahashi, Shunsuke Saito, SS Shim, TF Imperiale, Tomoko Hirakawa, Toshio Uraoka, WS Samowitz, Y Zhao, Yoshihiro Okumura   +45 more
core   +1 more source

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers [PDF]

, 2016
We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control.
Alexander, Richard, Archibald, Stephen J., Brown, Nathaniel J., Maneuski, Dzmitry, O’Shea, Val, Pamme, Nicole, Pimlott, Sally L., Tarn, Mark D.   +7 more
core   +2 more sources

A New Method for 18FDG generating using Geant4/ Gate7

Basic & Clinical Cancer Research, 2023
Fluorine 18-deoxyglucose is often used in Positron Emission Tomography devices. Positron Emission Tomography imaging is one of the useful tools which is used for cancer detection and its management.
Abuzar Shakeri, Ebrahim Heidari, Seyedeh Nasrin Hosseini Motlagh, Hamid Reza Vanaei   +3 more
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