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Production of reactive fluorine-18
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986Production conditions are reviewed from the perspective of maximizing activity--both total and specific--of 18F as electrophilic or nucleophilic precursors, with minimal levels of interfering species. Careful target design can avoid many pitfalls, and telemetry of a few key variables can guide the way to reproducible yields, consistent with prediction.
R J, Nickles +3 more
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The Preparation of Fluorine-18 Labelled Radiopharmaceuticals
The International Journal of Applied Radiation and Isotopes, 1977Abstract Progress in the preparation of fluorine-18 labelled radiopharmaceuticals is reviewed. The pharmacology and design of 18F-labelled organic compounds of biomedical interest, production of the radionuclide and methods of labelling which have been used to date are discussed. Emphasis has been placed on the practical chemical problems encountered,
A K, Horsch +3 more
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Therapy Monitoring with Fluorine-18 FDG-PET and Fluorine-18 FDG-PET/CT
PET Clinics, 2008PET with the glucose analog [18F]-FDG is increasingly used to monitor tumor response in patients undergoing chemotherapy and chemoradiotherapy. The clinical value of FDG PET for differentiation of residual tumor and therapy-induced fibrosis has been documented for gastrointestinal cancer.
Hinrich A, Wieder, Ken, Herrmann
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Metabolism of Fluorine 18 in Domestic Animals
American Journal of Physiology-Legacy Content, 1955Amounts of F/sup 18/ sufficient to permit studies up to 10 hours duration in domestic animals with non-toxic levels of total fluorine have become available from cyclotron production. The initial rate of disappearance of intravenously injected F/sup 18/ from the blood was found to be 41 and 32% of the dose/min.
J D, PERKINSON +4 more
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Preparation of carrier-free fluorine-18
The International Journal of Applied Radiation and Isotopes, 1977Abstract A method for the preparation of carrier-free fluorine-18 using a column of hydrous stannic oxide is described. The adsorption and desorption characteristics of the fluoride ion on the column has been investigated using F-18 as a tracer. The present study has confirmed that the fluoride ion is practically completely adsorbed on the column in ...
T H, Hsieh +3 more
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A cyclotron method for the production of fluorine-18
The International Journal of Applied Radiation and Isotopes, 1966Abstract Fluorine-18 is produced, with yields of up to 40 mc/hr, by the bombardment of water contained in a suitable target held in the external α-particle beam of a 30 MeV cyclotron: a method is described which is in routine use to produce samples for medical research purposes.
J C, Clark, D J, Silvester
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Journal of Nuclear Science and Technology, 1964
Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
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Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
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Recommendations for fluorine-18 production
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1991Abstract Data for the production of fluorine-18 (t 1/2 = 109.6 min; β + = 100%) are reviewed. The experience of some well-established European centres for positron emission tomography (PET), in the routine production of fluorine-18 for the purpose of labelling radiopharmaceuticals, is described.
Guillaume, Marcel +5 more
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