Results 1 to 10 of about 3,516 (103)

Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer genes (BRCA) mutations.
Gianluca Destro, Rebecca Rizzo, Chiara Rua, Raha Rouhbakhsh Azimi, Silvia Morbelli   +4 more
doaj   +2 more sources

Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter

Pharmaceutics, 2023
Purpose: A new PET radiotracer 18F-AF78 showing great potential for clinical application has been reported recently. It belongs to a new generation of phenethylguanidine-based norepinephrine transporter (NET)-targeting radiotracers. Although many efforts
Anna Tutov, Xinyu Chen, Rudolf A. Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, Takahiro Higuchi   +9 more
doaj   +1 more source

Single center experience on the production of fluorine-18 radiopharmaceuticals using a 7.5 MeV cyclotron: capabilities and challenges

SN Applied Sciences, 2020
A plethora of cyclotron options have been developed to fulfil the demands of nuclear medicine industries in PET and SPECT radioisotopes. As a remote site, the difficulties of transporting fluorine 18 radiopharmaceuticals for PET examinations were ...
Andreas Fesas, Mohammad Reza Pourkhessalian, Alexis Vrachimis   +2 more
doaj   +1 more source

Spectro-Fluor™ Technology for Reliable Detection of Proteins and Biomarkers of Disease: A Pioneered Research Study

Diagnostics, 2014
Quantitative and qualitative characterization of fluorinated molecules represents an important task. Fluorine-based medicinal chemistry is a fast-growing research area due to the positive impact of fluorine in drug discovery, and clinical and molecular ...
Farid Menaa, Bouzid Menaa, Olga N. Sharts   +2 more
doaj   +1 more source

Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements

Physics in Medicine & Biology, 2018
In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources.
Jose M Anton-Rodriguez, Georgios Krokos, Fotis Kotasidis, Marie-Claude Asselin, Olivia Morris, Peter Julyan, Anthony Archer, Julian C Matthews   +7 more
openaire   +4 more sources

Radiolabeling Strategies for Tumor-Targeting Proteinaceous Drugs

Molecules, 2014
Owing to their large size proteinaceous drugs offer higher operative information content compared to the small molecules that correspond to the traditional understanding of druglikeness.
Grant Sugiura, Helen Kühn, Max Sauter, Uwe Haberkorn, Walter Mier   +4 more
doaj   +1 more source

Dose Calibrator Linearity Testing: Radioisotope 99mTc or 18F? An Alternative for Reducing Costs in Nuclear Medicine Quality Control

World Journal of Nuclear Medicine, 2015
Dose calibrator linearity testing is indispensable for evaluating the capacity of this equipment in measuring radioisotope activities at different magnitudes, a fundamental aspect of the daily routine of a nuclear medicine department, and with an impact ...
José Willegaignon, Marcelo Sapienza, George Coura-Filho, Alexandre Garcez, Carlos Alves, Marissa Cardona, Ricardo Gutterres, Carlos Buchpiguel   +7 more
doaj   +1 more source

Folate-Based Radiotracers for PET Imaging—Update and Perspectives

Molecules, 2013
The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive tumors, allowing specific delivery of attached probes to the ...
Cristina Müller
doaj   +1 more source

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

EJNMMI Research, 2017
Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis, Mirkka Sarparanta   +9 more
doaj   +1 more source

Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats

Frontiers in Pharmacology
ObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine was ...
Yingtong Lu, Yan Cui, Lu Hou, Yuanfang Jiang, Jingjie Shang, Lu Wang, Hao Xu, Weijian Ye, Yang Qiu, Bin Guo   +9 more
doaj   +1 more source