Results 11 to 20 of about 3,516 (103)

Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization

Angewandte Chemie, Volume 138, Issue 8, 16 February 2026.
We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde, Jonatan Babiker, Michelle Mebrahtu, Anaïs Prigent, Gauthier Foucras, Yogesh N. Aher, Francoise M. Amombo Noa, Magnus J. Johansson, Janez Košmrlj, Ross D. Jansen‐van Vuuren, Thomas Cailly, Henrik Sundén   +11 more
wiley   +2 more sources

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Carbon‐14 Perovskite Betavoltaics Reach Record 10.79% Efficiency

Carbon Energy, Volume 8, Issue 5, May 2026.
A perovskite‐based betavoltaic cell incorporating carbon‐14 nanoparticles and formamidinium lead iodide achieves a record energy conversion efficiency of 10.79%. The device design enhances charge generation through an electron avalanche multiplication mechanism.
Hong Soo Kim, Ryan Rhee, Junho Lee, Muhammad Bilal Naseem, Jung Hwan Lee, Jong Hyeok Park, Su‐Il In   +6 more
wiley   +1 more source

Fluorine‐18 Fluorodeoxyglucose‐Positron Emission Tomography/Computed Tomography for Detection of Lymph Node Metastasis in Canine Mast Cell Tumour

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 197-207, March 2026.
ABSTRACT Lymph node (LN) metastasis has been associated with shorter survival times in dogs with mast cell tumour (MCT), and treatment of metastatic LN with lymphadenectomy or irradiation has been demonstrated to improve outcomes. Identification of metastatic LN in dogs with MCT is therefore of both prognostic and therapeutic significance.
Alison C. Williams, Monique N. Mayer, Ryan M. Dickinson, Sally L. Sukut, Valerie S. MacDonald‐Dickinson, Jerome Gagnon   +5 more
wiley   +1 more source

DOES PET/CT WITH 18F-FLUOROESTRADIOL (18F-FES) CONTRIBUTE TO THE ASSESSMENT OF BREAST CANCER COMPARED TO FLUORINE-2-D-DEOXYGLUCOSE (18F-FDG)?

Hematology, Transfusion and Cell Therapy
Introduction/Justification: While fluorine-2-D-deoxyglucose (18F-FDG) PET/CT is commonly used in the assessment of breast cancer, it has limitations, such as its inability to distinguish it from inflammatory and infectious conditions.
Bruno Russiano de Oliveira Boeno, Yuri Aguillera Pedreira, Marcelo Moreira da Silva, Carla Lima Santos Viviani, Leonardo Fonseca Monteiro do Prado   +4 more
doaj   +1 more source

Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2‐nitroimidazole TAT Conjugate

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal, Akanksha Jain, Ashwini Babu, Chandan Kumar, Madhava B. Mallia   +4 more
wiley   +1 more source

Integrating Nuclear Medicine Services Into Health Care Systems in Low‐ and Middle‐Income Countries: A Review of Challenges and Innovations

iRADIOLOGY, Volume 4, Issue 1, Page 3-12, February 2026.
Nuclear medicine is capable of solving noncommunicable diseases in LMICs but poses its own challenges. Research and investments are still needed. For nuclear medicine to answer the dynamics of noncommunicable diseases in the LMICs, it would have to overcome the high costs and regulations involved in this practice.
Biruk Demisse Ayalew, Saim Mahmood Khan, Helina K. Teklehaimanot, Zebeaman Tibebu Gorfu, Biniyam Jemaneh Batu, Zemichael Getu Alemayehu, Brook Lelisa Sime, Eyerusalem Kebede Zewde, Temesgen Mamo Sharew, Muhidin Ibrahim Hundisa, Yeamlak Tariku Tewodros, Jawairya Muhammad Hussain, Barina Khan   +12 more
wiley   +1 more source

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source