Results 61 to 70 of about 53,359 (237)
Beilstein Journal of Organic Chemistry, 2017 Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers.
Thomas Lee Collier +4 more
doaj +1 more source
Production of fluorine-18 from reactor-irradiated lithium compounds [PDF]
, 1968 Existing methods of separating fluorine-18 produced in reactor-irradiated lithium compounds are reviewed. Direct distillation of fluorine-18 from acidified lithium solutions and absorption with the minimum of condensation is shown to be the most ...
Robson, J
core
Organometallic fluorine-18 bonds in 18F-radiochemistry [PDF]
, 2021 Fluorine-18 is by far the most widely exploited radionuclide in PET (positron emission tomography) radiochemistry. The physical half-life of fluorine-18 allows for chemical manipulation within a restricted timeframe, and cyclotron-produced fluoride ion
전중현, 전중현
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Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK [PDF]
Organic & Biomolecular Chemistry, 2016 A rapid, efficient single continuous process for peptide synthesis, cyclization, and radiolabeling on solid-support with a single purification step afforded a high purity radiotracer.
Davis, Ryan A +3 more
openaire +4 more sources
The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
Molecules, 2022 MerTK (Mer tyrosine kinase), a receptor tyrosine kinase, is ectopically or aberrantly expressed in numerous human hematologic and solid malignancies. Although a variety of MerTK targeting therapies are being developed to enhance outcomes for patients ...
Li Wang +9 more
doaj +1 more source
Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes [PDF]
Bioconjugate Chemistry, 2014 Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β(+) decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive ...
Orit Jacobson +2 more
openaire +3 more sources
Fluorine-18 capture by substituted BODIPY derivatives [PDF]
For the medical community to effectively decrease the number of deaths caused by cancer each year, we must develop tools that allow for the early detection of biological abnormalities. Earlier detection is key to increasing the survival rate among cancer
Cavins, Patrick L.
core +1 more source
, 2020 INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan +12 more
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EJNMMI Research, 2017 Background We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (18F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeoxyglucose (18F-FDG) PET in 38 ...
Keishi Horiguchi +8 more
doaj +1 more source
Pharmaceuticals, 2021 Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing 18F-labeled compounds based on the small molecule inhibitor SP-141 for
Satish K. Chitneni +3 more
doaj +1 more source