Results 31 to 40 of about 316 (156)

Chiral fluoroacetic acid: synthesis of (R)- and (S)-[H-2(1)]-fluoroacetate in high enantiopurity

open access: yes, 2013
A two-step synthesis of (R)- and (S)-[H-2(1)]-fluoroacetate (sodium salts) in high enantioselectivity is reported. The synthesis is the development of a previous one in which the enantioselectivity has been increased from similar to 38% ee to >95% ee.
Wadoux, Rudy D. P.   +3 more
core   +1 more source

Sequential Optimization Approach Toward an Azapeptide‐Based SARS‐CoV‐2 Main Protease Inhibitor

open access: yesArchiv der Pharmazie, Volume 358, Issue 12, December 2025.
A series of small‐molecule azapeptides with various cysteine‐reactive electrophilic groups was designed, synthesized, and investigated for Mpro inhibition. Particularly suitable warheads were identified, and their linkage to a structurally expanded peptidomimetic scaffold afforded the potent lead compound 12, with kinac/Ki = 78,900 M–1s–1 and an ...
Rabea Voget   +9 more
wiley   +1 more source

Invasive Predator Management Can Mitigate the Impacts of Fire and Low Rainfall for Some Herpetofauna

open access: yesEcology and Evolution, Volume 15, Issue 12, December 2025.
Fire, invasive predators, and drought are major threats for herpetofauna. These key global drivers are known to interact, yet, research investigating their interactive effects on wildlife remains limited. We found the management of invasive predators could partially mitigate the negative effects of prescribed fire and low rainfall for some species ...
Kristina J. Macdonald   +3 more
wiley   +1 more source

Origins and diversity of invasive brushtail possums (Trichosurus vulpecula) in New Zealand surveyed with mtDNA haplotype and nuclear microsatellite data

open access: yesNew Zealand Journal of Zoology, Volume 52, Issue 5, Page 682-703, December 2025.
ABSTRACT The brushtail possum Trichosurus vulpecula is native to Australia where six subspecies exist in distinct regions. A composite invasive population is established in Aotearoa New Zealand, which has since been subject to localised bouts of culling.
Nimeshika Pattabiraman   +2 more
wiley   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

open access: yesInterdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen   +5 more
wiley   +1 more source

Construction and Characterization of Novel Shuttle Expression Vectors for Actinobacillus succinogenes

open access: yesBiotechnology and Applied Biochemistry, Volume 72, Issue 5, Page 1265-1273, October 2025.
ABSTRACT Actinobacillus succinogenes is a ruminal microorganism of biotechnological importance due to its capacity to produce succinic acid at high yields. Despite the scientific interest in this organism, molecular vehicles for the transfer and expression of genetic material are limited compared to the existing demand.
Angélica Vallejo‐Giraldo   +7 more
wiley   +1 more source

Ion chromatographic determination of haloacetates in environmental samples

open access: yes, 2005
A method is reported for the sensitive, simultaneous determination of mono-, di-, and trifluoroacetates by ion chromatography. These species were separated using a Dionex AS17 anion-exchange column employed with a potassium hydroxide gradient (via a ...
Wang, F (15492413)
core   +1 more source

Halide Abstraction from Halogenated Acetate Ligands by Actinyls: A Competition between Bond Breaking and Bond Making

open access: yes, 2016
Transfer of halogen atoms from halogenated acetate ligands, CX3CO2 (X = F, Cl, Br), to actinyls, AnO22+ (An = U, Np, Pu) is stimulated by collision-induced dissociation (CID) in a quadrupole ion trap. CID of [AnO2(CF3CO2)3]− complexes results exclusively
Phuong D. Dau (1311153)   +1 more
core   +1 more source

Simultaneous determination of monofluoroacetate, difluoroacetate and trifluoroacetate in environmental samples by ion chromatography

open access: yes, 2004
A method is reported for the sensitive, simultaneous determination of mono- (MFA), di- (DFA), and trifluoroacetates (TFA) by ion chromatography (IC).
Gregory Dicinoski (14735224)   +3 more
core  

Simultaneous Determination of Fluoroacetates, Chloroacetates, and Bromoacetates in Soil Samples by Ion Chromatography

open access: yes, 2004
A comparative study was made of the chromatographic behaviour of nine haloacetic acids, namely mono-, di-, and tri-fluoroacetate (MFA, DFA, and TFA, respectively); mono-, di-, and tri-chloroacetate (MCA, DCA, and TCA, respectively); and mono-, di- and ...
Gregory Dicinoski (14735224)   +3 more
core  

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