Results 31 to 40 of about 316 (156)
Chiral fluoroacetic acid: synthesis of (R)- and (S)-[H-2(1)]-fluoroacetate in high enantiopurity
A two-step synthesis of (R)- and (S)-[H-2(1)]-fluoroacetate (sodium salts) in high enantioselectivity is reported. The synthesis is the development of a previous one in which the enantioselectivity has been increased from similar to 38% ee to >95% ee.
Wadoux, Rudy D. P. +3 more
core +1 more source
Sequential Optimization Approach Toward an Azapeptide‐Based SARS‐CoV‐2 Main Protease Inhibitor
A series of small‐molecule azapeptides with various cysteine‐reactive electrophilic groups was designed, synthesized, and investigated for Mpro inhibition. Particularly suitable warheads were identified, and their linkage to a structurally expanded peptidomimetic scaffold afforded the potent lead compound 12, with kinac/Ki = 78,900 M–1s–1 and an ...
Rabea Voget +9 more
wiley +1 more source
Invasive Predator Management Can Mitigate the Impacts of Fire and Low Rainfall for Some Herpetofauna
Fire, invasive predators, and drought are major threats for herpetofauna. These key global drivers are known to interact, yet, research investigating their interactive effects on wildlife remains limited. We found the management of invasive predators could partially mitigate the negative effects of prescribed fire and low rainfall for some species ...
Kristina J. Macdonald +3 more
wiley +1 more source
ABSTRACT The brushtail possum Trichosurus vulpecula is native to Australia where six subspecies exist in distinct regions. A composite invasive population is established in Aotearoa New Zealand, which has since been subject to localised bouts of culling.
Nimeshika Pattabiraman +2 more
wiley +1 more source
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen +5 more
wiley +1 more source
ABSTRACT Actinobacillus succinogenes is a ruminal microorganism of biotechnological importance due to its capacity to produce succinic acid at high yields. Despite the scientific interest in this organism, molecular vehicles for the transfer and expression of genetic material are limited compared to the existing demand.
Angélica Vallejo‐Giraldo +7 more
wiley +1 more source
Ion chromatographic determination of haloacetates in environmental samples
A method is reported for the sensitive, simultaneous determination of mono-, di-, and trifluoroacetates by ion chromatography. These species were separated using a Dionex AS17 anion-exchange column employed with a potassium hydroxide gradient (via a ...
Wang, F (15492413)
core +1 more source
Transfer of halogen atoms from halogenated acetate ligands, CX3CO2 (X = F, Cl, Br), to actinyls, AnO22+ (An = U, Np, Pu) is stimulated by collision-induced dissociation (CID) in a quadrupole ion trap. CID of [AnO2(CF3CO2)3]− complexes results exclusively
Phuong D. Dau (1311153) +1 more
core +1 more source
A method is reported for the sensitive, simultaneous determination of mono- (MFA), di- (DFA), and trifluoroacetates (TFA) by ion chromatography (IC).
Gregory Dicinoski (14735224) +3 more
core
A comparative study was made of the chromatographic behaviour of nine haloacetic acids, namely mono-, di-, and tri-fluoroacetate (MFA, DFA, and TFA, respectively); mono-, di-, and tri-chloroacetate (MCA, DCA, and TCA, respectively); and mono-, di- and ...
Gregory Dicinoski (14735224) +3 more
core

