Results 71 to 80 of about 129,172 (353)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Glyphosate in waters and soils from genetically modified canola cultivation in Parkes, NSW, Australia [PDF]

, 2013
Investigations were conducted of farmland from the Parkes region of New South Wales, Australia, cultivated with genetically modified canola, involving the determination of glyphosate (N-(phosphonomethyl)glycine) concentrations in water and soils, and its
Badek, Kate, Nahar, Kamrun, Niven, Robert K., Pearson, Stuart, Rahman, A. F. Mokhlesur, Riesen, Hans   +5 more
core  

Detection of DNA-RNA hybrids in vivo [PDF]

, 2017
DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they may be an important source of genome instability, a hallmark of cancer and genetic diseases.
Aguilera López, Andrés, Barroso Ceballos, Sonia Inés, García Rubio, María Luisa   +2 more
core   +1 more source

Author Correction: Floats with bio-optical sensors reveal what processes trigger the North Atlantic bloom

Nature Communications, 2018
In the original version of this Article, the data accession https://doi.org/10.17882/42182 was omitted from the Data Availability statement. In the first paragraph of the Methods subsection entitled ‘Float data processing’, the WET Labs ECO-triplet ...
A. Mignot, R. Ferrari, H. Claustre
doaj   +1 more source

Comparing Vertical Distributions of Chl-a Fluorescence, Marine Snow, and Taxon-Specific Zooplankton in Relation to Density Using High-Resolution Optical Measurements

Frontiers in Marine Science, 2020
Interactions between predators and their prey are important in shaping planktonic ecosystems. However, these interactions are difficult to assess in situ at the spatial scales relevant to the organisms.
Christian Briseño-Avena, Christian Briseño-Avena, Jennifer C. Prairie, Peter J. S. Franks, Jules S. Jaffe   +4 more
doaj   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source

Blue-fluorescence of NADPH as an indicator of marine primary production [PDF]

, 2004
Nicotinamide Adenine Dinucleotide Phosphate (NADPH) is the primary product of photosynthesisand can therefore serve as an indicator of biomass and photosynthetic activity.
Grossart, H-P., Reuter, R., Steigenberger, S., Terjung, F.   +3 more
core  

Dispersal-mediated trophic interactions can generate apparent patterns of dispersal limitation in aquatic metacommunities [PDF]

, 2012
Dispersal is a major organising force in metacommunities, which may facilitate compositional responses of local communities to environmental change and affect ecosystem function.
Agrawal, Beisner, Bohonak, Chase, Cherif, Cottenie, Cottenie, Daufresne, Declerck, Duffy, Finlay, Finlay, Flössner, Giroldo, Gonzalez, Hambright, Hillebrand, Howeth, Howeth, Jenkins, Jürgens, Jürgens, Lampert, Langenheder, Legendre, Leibold, Lepš, Loreau, Loreau, Matthiessen, Matveev, Mayeli, McCauley, Michels, Mouquet, Naeslund, Ozinga, Pandit, Peres-Neto, Pärtel, R Development Core Team, Sarnelle, Scheffer, Sherr, Shurin, Staddon, Van der Gucht, Vanormelingen, Zollner   +48 more
core   +4 more sources