Results 81 to 90 of about 132,621 (262)
Soft Hardware, Flowing Software: Reconfigurable Microfluidics for Adaptable Chemical Computation
Advanced Materials, EarlyView.A reconfigurable microfluidic platform based on soft, photo‐printable, and chemically erasable hydrogel structures printed and erased in situ is used to control flow routing, mixing, chemical patterning, and even chemical computing. Using hardware to control chemical computations decouples logic function from molecular composition, demonstrated via ...
Piet J. M. Swinkels +4 more
wiley +1 more source
Near-infrared MINFLUX imaging enabled by suppression of fluorophore blinking. [PDF]
Sci AdvMINimal photon FLUXes (MINFLUX) offers nanometer localization precision, with lower fluorophore requirements than for other super-resolution microscopy (SRM) techniques.
Srambickal CV +8 more
europepmc +2 more sources
Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets
Advanced Materials Technologies, EarlyView.This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu +7 more
wiley +1 more source
Cholesterol-Fluorophore Bioconjugates [PDF]
This experiment focuses on attaching a cholesterol group to the fluorophore, 9,10-anthracenedione. Cholesterol is a structural component of cell membranes, and its lipophilic properties allow it to pass through the phospholipid bilayer.1 Anthraquinones ...
Bayliss, Emily
core
Concatenation of fluorophore emission spectra recorded with multiple excitation wavelengths.
, 2016 Graphic representation of the m × n matrix of fluorophore emission spectra. Each column represents the spectrum of one fluorophore and each row represents the normalized intensities of the fluorophores at a particular excitation / emission wavelength ...
Rudolf Oldenbourg (1859872) +2 more
core +1 more source
Advanced Materials Technologies, EarlyView.A compact incubation platform enables long‐term cultivation of biological samples directly on diamond quantum sensors for NV widefield magnetometry. The 3D‐printed biocompatible chamber provides a temperature controlled, CO2${\rm CO}_2$ and humidity rich environment while accommodating total internal reflection excitation geometry.
Andre Pointner +9 more
wiley +1 more source
Synthesis of Fluorophore-Tagged Xylosides That Prime Glycosaminoglycan Chains
, 2015 Biosynthesis and functions of glycosaminoglycan (GAG) chains are complex and remain elusive. To better understand the factors that regulate the biosynthesis and functions, fluorophore-tagged xylosides carrying two different linkages between fluorophore ...
Balagurunathan Kuberan (1308300) +1 more
core +1 more source
Advanced Optical Materials, EarlyView.A proline‐integrated donor–acceptor fluorophore enables multifunctional luminescence through rational molecular design. Water‐vapor‐responsive mechanochromic luminescence (MCL) with circularly polarized luminescence (CPL) switching and efficient visualization of latent fingerprints (LFPs) are realized from this single small organic molecule.
Hao Chen +3 more
wiley +1 more source
Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source