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Fluoroquinolones: Blessings Or Curses.
Current Drug Targets, 2020Fluoroquinolones are one of the world's most valuable and popularly used categories of antimicrobial agents. This paper attempts to review the substantial progress of fluoroquinolones from its discovery to black box warning.
P. P. Majalekar, P. Shirote
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Mayo Clinic Proceedings, 1991
The fluoroquinolone class of antibiotics promises to become as diverse and as important as beta-lactam agents. The fluoroquinolones inhibit bacterial DNA gyrase and are bactericidal. All fluoroquinolones have potent activity against most gram-negative bacteria; ciprofloxacin is the most active against Pseudomonas aeruginosa.
R C, Walker, A J, Wright
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The fluoroquinolone class of antibiotics promises to become as diverse and as important as beta-lactam agents. The fluoroquinolones inhibit bacterial DNA gyrase and are bactericidal. All fluoroquinolones have potent activity against most gram-negative bacteria; ciprofloxacin is the most active against Pseudomonas aeruginosa.
R C, Walker, A J, Wright
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Infectious Disease Clinics of North America, 2000
The fluoroquinolone class of antimicrobial agents has expanded dramatically in the last 5 years and will continue to grow over the next decade. This article discusses the newer fluoroquinolones in detail, including pharmacokinetics, pharmacodynamics, safety, and drug interactions, and the spectrum of in vitro activity.
J A, O'Donnell, S P, Gelone
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The fluoroquinolone class of antimicrobial agents has expanded dramatically in the last 5 years and will continue to grow over the next decade. This article discusses the newer fluoroquinolones in detail, including pharmacokinetics, pharmacodynamics, safety, and drug interactions, and the spectrum of in vitro activity.
J A, O'Donnell, S P, Gelone
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The Newer Fluoroquinolones [PDF]
Medical Clinics of North America, 2009 Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
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Ophthalmology, 2009
To report a possible association between fluoroquinolones and diplopia.Database study.A total of 171 subjects were studied.Spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, World Health Organization, and Food and Drug Administration were collected on fluoroquinolones and diplopia.Data garnered from the spontaneous ...
Frederick W. Fraunfelder +1 more
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To report a possible association between fluoroquinolones and diplopia.Database study.A total of 171 subjects were studied.Spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, World Health Organization, and Food and Drug Administration were collected on fluoroquinolones and diplopia.Data garnered from the spontaneous ...
Frederick W. Fraunfelder +1 more
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Fluoroquinolone Use and Fluoroquinolone Resistance: Is There an Association?
Clinical Infectious Diseases, 1994In an assessment of potential risk factors for nosocomial infections caused by fluoroquinolone-resistant gram-negative organisms, 68 patients who developed a nosocomial infection caused by a fluoroquinolone-resistant gram-negative bacillus were compared with 191 patients who developed a nosocomial infection caused by a fluoroquinolone-susceptible gram ...
Hervé Richet +6 more
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Current Trends and Future Directions of Fluoroquinolones.
Current Medicinal Chemistry, 2019Fluoroquinolones represent an interesting synthetic class of antimicrobial agents with broad spectrum and potent activity. Since the discovery of nalidixic acid, the prototype of quinolones, several structural modifications to the quinolone nucleus have ...
Hamada H. H. Mohammed +3 more
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Towards anticancer fluoroquinolones: A review article
Archiv der Pharmazie, 2019Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti‐cancer drugs, such as doxorubicin, can achieve antitumor activity via poisoning ...
M. Abdel-Aal +3 more
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Fluoroquinolones and tuberculosis
Expert Opinion on Investigational Drugs, 2002Tuberculosis (TB) remains one of the main causes of morbidity worldwide, and the emergence of multi-drug resistant (MDR) Mycobacterium tuberculosis strains in some parts of the world has become a major concern. The decrease in activity of the major anti-TB drugs, such as isoniazid and rifampicin, is an important threat and alternative therapies are ...
André Bryskier, John Lowther
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Mayo Clinic Proceedings, 1999
The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
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The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
openaire +2 more sources