Results 71 to 80 of about 14,712 (219)

Rational use of the fluoroquinolones

South African Medical Journal, 2019
The systemic fluoroquinolones (FQs) have recently been reported to be associated with significant side-effects in susceptible individuals. This has prompted the Food and Drug Administration (FDA) in the USA and the European Medicines Agency (EMA) to issue warnings regarding their use.
Richards, G A, Brink, A J, Feldman, C
openaire   +3 more sources

Association between preexisting long‐term care needs and in‐hospital mortality and long‐term outcomes in older inpatients with pneumonia: A retrospective cohort study

Journal of General and Family Medicine, EarlyView.
Abstract Background Limited evidence exists regarding the impact of baseline functional and cognitive impairments on the outcomes of patients with pneumonia. Methods We used medical and long‐term care administrative databases in a prefecture in Japan that contained care need levels assessed using the national standardized certification system.
Jumpei Taniguchi, Hayato Yamana, Yuichiro Matsuo, Yusuke Sasabuchi, Hiroki Matsui, Takahide Kohro, Hideo Yasunaga   +6 more
wiley   +1 more source

Evaluating antimicrobial effectiveness in acute uncomplicated cystitis: A retrospective single‐center study

Journal of General and Family Medicine, EarlyView.
Abstract Background Acute uncomplicated cystitis (AUC) is a urinary tract infection and is generally treated using antimicrobial therapy. Escherichia coli is the main causative agent of AUC. Recently, the prevalence of fluoroquinolone (FQ)‐resistant‐E. coli has demonstrated a noticeable increase. In this study, we aimed to investigate the effectiveness
Takuhisa Nukaya, Kiyohito Ishikawa, Ryoichi Shiroki   +2 more
wiley   +1 more source

Chloromethane‐Enabled Quaternization of Linear Polyglycerol Amines and Their Application as Antibacterial Agents

Macromolecular Rapid Communications, EarlyView.
This study details a scalable process for synthesizing quaternary ammonium compounds (QACs) from linear polyglycerols using gaseous chloromethane. The resulting compounds demonstrate effective antibacterial and antibiofilm properties against drug‐resistant S.
Natalie Hanheiser, Merlin Kleoff, Katharina Achazi, Abhishek Singh, Sebastian Riedel, Rainer Haag   +5 more
wiley   +1 more source

Ciprofloxacin, an antibiotic with cardiac actions on isolated rat hearts [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: Ciprofloxacin is the most commonly used fluoroquinolone and is prescribed as the antibiotic of choice in the treatment of several microbial infections.
Loipa Galán-Martínez, Alberto D. Calderín-Pulido, Alicia Fleites-Vázquez, Julio L. Álvarez   +3 more
doaj  

Fluoroquinolones and aortic aneurysms: Which fluoroquinolones are at risk?

Archives of Cardiovascular Diseases Supplements, 2019
A recent cohort study described a 66% increased rate of aortic aneurysms in patients receiving fluoroquinolones (Pasternak et al. BMJ 2018; 360:k678). The authors did not study the different fluoroquinolones. The present study was performed to investigate the fluoroquinolones more at risk of aortic aneurysms.
Vanessa Rousseau, G. Montastruc, Agnès Sommet, François Montastruc, Jean-Louis Montastruc, Justine Benevent, Leila Chebane   +6 more
openaire   +2 more sources

Infectious Morbidity During Pediatric Acute Myeloid Leukemia Chemotherapy in a High‐Income Country: A 15‐Year Population‐Based Overview

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Infection causes significant morbidity and mortality in pediatric acute myeloid leukemia (pAML). This study describes the incidence and risk factors of bloodstream infection (BSI) and invasive fungal infection (IFI) in pAML. Methods A retrospective chart review was performed of patients treated according to the ANLL‐97/AML‐12 (N =
Emily R. Schwartz, Kim Klein, Birgit I. Lissenberg‐Witte, Tom F. W. Wolfs, Valérie de Haas, Bianca Goemans, Natasja Dors, Marry M. van den Heuvel‐Eibrink, Rutger R. G. Knops, Wim J. E. Tissing, Birgitta A. Versluys, C. Michel Zwaan, Raphaële R. L. van Litsenburg, Gertjan J. L. Kaspers   +13 more
wiley   +1 more source

Pharmacokinetics of continuous infusion ceftolozane/tazobactam in two patients with extensive total body surface area burns

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Introduction Treatment of infections in patients with burn injuries is challenging due to altered antimicrobial pharmacokinetics. Continuous infusion β‐lactam therapy may be a useful antimicrobial stewardship strategy to improve pharmacodynamic target attainment in this population.
Jay D. Olivet, Megan Amerson‐Brown, Juan J. Calix, Emma Graffice, Tyson Kilpatrick, Hanna F. Roenfanz, David P. Nicolau, Joseph L. Kuti, Matthew L. Brown   +8 more
wiley   +1 more source

Detection of Resistance to Fluoroquinolones and Second-Line Injectable Drugs Among Mycobacterium tuberculosis by a Reverse Dot Blot Hybridization Assay

Infection and Drug Resistance, 2020
Guilian Li,1,* Qian Guo,1,2,* Haican Liu,1 Li Wan,1 Yi Jiang,1 Machao Li,1 Li-li Zhao,1 Xiuqin Zhao,1 Zhiguang Liu,1 Kanglin Wan1 1State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and ...
Li G, Guo Q, Liu H, Wan L, Jiang Y, Li M, Zhao LL, Zhao X, Liu Z, Wan K   +9 more
doaj  

Fluoroquinolones and the risk of aortic aneurysm or dissection: A population‐based propensity score‐matched German cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Objective To investigate the risk of aortic aneurysm or dissection associated with fluoroquinolone (FQ) prescription compared to macrolides in German routine health care data in order to replicate the recent study (Pharmacotherapy 2023;43:883) extending the results by contributing evidence for six additional broad‐spectrum antibiotic classes ...
Julia Wicherski, Jonas Peltner, Cornelia Becker, Katrin Schüssel, Gabriela Brückner, Andreas Schlotmann, Helmut Schröder, Winfried V. Kern, Britta Haenisch   +8 more
wiley   +1 more source