Results 311 to 320 of about 283,224 (387)

Emergence of PALB2 Reversion Mutations as a Mechanism of Resistance to Niraparib in Breast Cancer: A Case Report

Cancer Science, EarlyView.
This case study describes the clinical course of a 39‐year‐old woman with metastatic breast cancer harboring a germline PALB2 mutation who was treated with a PARP inhibitor. Figure shows the PALB2 reverse mutation detected by liquid biopsy genomic profiling. The top panel shows a schematic diagram of the wild‐type PALB2 sequence. The second panel shows
Maako Kawamura, Hiroshi Tada, Hidekazu Shirota, Miki Dobashi, Noriko Takenaga, Hiroyuki Yasojima, Narumi Harada‐shoji, Keigo Komine, Kenichi Nakamura, Minoru Miyashita, Hisato Kawakami   +10 more
wiley   +1 more source

Correction to "SPARC Promotes Aerobic Glycolysis and 5-Fluorouracil Resistance in Colorectal Cancer Through the STAT3/HK2 Axis". [PDF]

Cancer Med
europepmc   +1 more source

Nutritional Status Assessment Using the Patient-Generated Subjective Global Assessment (PG-SGA) in Individuals with Colorectal Cancer Undergoing Chemotherapy Regimens. [PDF]

J Clin Med
Sánchez-Diestro LE, Macias-Montero R, Ramalho-Galhanas AI, Aguiar-Frias AM, Paniagua-Vivas MS, Guerrero-Martín J.   +5 more
europepmc   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Population pharmacokinetic analysis of fluorouracil and oxaliplatin in the absence or presence of zolbetuximab in locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma. [PDF]

Cancer Chemother Pharmacol
Yamada A, Yang J, Bonate PL, Heo N, Poondru S.   +4 more
europepmc   +1 more source

Real‐world evidence of tirbanibulin in the treatment of actinic keratosis in Germany – prospective, multicenter, non‐interventional KLIR study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Tirbanibulin is an approved topical treatment for actinic keratosis (AK). This non‐interventional study investigated effectiveness and safety of tirbanibulin for AK. Patients and Methods The prospective KLIR‐study was conducted at 58 German dermatology centers (02/2022–09/2023).
Markus V. Heppt, Ina Hadshiew, Afra Kempf, Antje Melzer, Carola Berking   +4 more
wiley   +1 more source

Characterization and treatment of brain metastases from pancreatic cancer: a systematic review. [PDF]

Discov Oncol
Ma Y, He H, Li B, Lyu W, Qian W, Han L, Wang Z, Wei K.   +7 more
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Topical Chemotherapy for Ocular Surface Squamous Neoplasia: A Review of Adverse Effects and Their Clinical Management. [PDF]

Oncol Res
Corgiolu L, Giannaccare G, Cuccu A.
europepmc   +1 more source

FGFR2 Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan‐Asian Study

Hepatology Research, EarlyView.
FGFR2 Alterations in Young Adults with cholangiocarcinoma was common. Intrahepatic cholangiocarcinoma (ICC) is a rare liver cancer, typically seen in older adults. This study focused on younger patients across Asia, examining changes in the FGFR2 gene that may drive cancer growth.
Yuta Maruki, Yasushi Yatabe, Chiharu Mizoguchi, Kathleen Yasmin de Almeida, Aumkhae Sookprasert, Charuwan Akewanlop, Ming‐Huang Chen, Ekaphop Sirachainan, Dao Van Tu, Rozita Abdul Malik, Chaiyut Charoentum, Hwoei Fen Soo Hoo, Suhana Yusak, Tsung‐Hao Liu, Rangasamy Ramachandran, Patrapim Sunpaweravong, Pei Jye Voon, Najihah Abu Bakar, Junki Mizusawa, Hitomi Sumiyoshi Okuma, Kenichi Nakamura, Chigusa Morizane, Takuji Okusaka   +22 more
wiley   +1 more source