Results 341 to 350 of about 283,224 (387)
Some of the next articles are maybe not open access.
Cardiotoxicity of 5-Fluorouracil
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2006Cardiac side effects of the cytostatic agent 5-fluorouracil (5-FU) have an incidence of 1.2-7.6%. Potentially, arrhythmias, myocardial infarction and sudden cardiac death could occur. Life-threatening cardiotoxicity is rarely observed with a frequency
J. R. Schaefer +4 more
openaire +3 more sources
Gynecologic Oncology, 1990
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
David H. Moore +2 more
openaire +3 more sources
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
David H. Moore +2 more
openaire +3 more sources
Myocardiotoxicity of 5 Fluorouracil
Intensive Care Medicine, 1988We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the
A Caillette +4 more
openaire +2 more sources
Lacrimation and 5-Fluorouracil
Annals of Internal Medicine, 1978Excerpt To the editor: Recently Haidak, Hurwitz, and Yeung (1) reported in your journal that excessive lacrimation occurred in six patients receiving weekly injections of 5-fluorouracil during a pe...
N. Christophidis +3 more
openaire +3 more sources
Immunosuppression by 5-fluorouracil
Cancer, 1970Twelve patients with neoplasia undergoing therpay with 5-fluorouracil (5-FU) were immunized with Escherichia coli Vi antigen and tetanus toxoid to test the primary and secondary humoral immune responses. Skin sesitization was attempted with 2,4-dinitrochlorobenzene, and a battery of conmon microbial skin tests were applied during and after therapy ...
Malcolm S. Mitchell, Ronald C. Deconti
openaire +3 more sources
Administration of Fluorouracil
JAMA, 1963To the Editor: —This letter is written to challenge the conclusions drawn by Dr. Lemon and associates in their article "Decreased Intoxication by Fluorouracil When Slowly Administered in Glucose" ( JAMA 185 :1012 [Sept 28] 1963). Since acceptance of the conclusions of these authors could lead to widespread "office practice" use of this method of ...
Charles G. Moertel +1 more
openaire +2 more sources
Fluorouracil and Suprachoroidal Hemorrhage
Archives of Ophthalmology, 1987To the Editor. —Frenkel and Shin 1 have presented "a somewhat different picture... regarding the predisposing factors... in delayed suprachoroidal hemorrhages." While their impression that aphakia is an important predisposing factor concurs with previous reports, 2-4 we find little support for their assertion that the use of fluorouracil is a risk ...
Michael G. Gressel, Richard K. Parrish
openaire +3 more sources
Fluorouracil and Colorectal Cancer
JAMA: The Journal of the American Medical Association, 1977To the Editor.— The disagreement between Moertel (236:1935, 1976) and Li (237:872, 1977) regarding the value of fluorouracil as an adjuvant agent can be reconciled if the factors of angiogenesis and selective solubilization of fluorouracil are taken into account.
Bernard Ecanow +2 more
openaire +3 more sources
General Pharmacology: The Vascular System, 1998
1. Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of choice in the treatment of, for example, colorectal cancer, circumvention of resistance is of vital importance. 2.
Günther G. Steger +2 more
openaire +2 more sources
1. Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of choice in the treatment of, for example, colorectal cancer, circumvention of resistance is of vital importance. 2.
Günther G. Steger +2 more
openaire +2 more sources
Thymidylate Synthase and Fluorouracil
1988A knowledge of the catalytic mechanism of thymidylate synthase (TS), and its inhibition by 5-fluorodeoxyuridylate (FdUMP) was instrumental in developing the FUra-CF combination for cancer chemotherapy. The generation of the ideas which led to the current combination cleary demonstrates the importance of a fundamental knowledge of the interactions of ...
Daniel V. Santi, Kathryn M. Ivanetich
openaire +3 more sources